Journal ArticleDOI
Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
Jiangfeng Du,Jiangfeng Du,Zhanjun Gu,Liang Yan,Yuan Yong,Xuan Yi,Xiao Zhang,Jing Liu,Renfei Wu,Cuicui Ge,Chunying Chen,Chunying Chen,Chunying Chen,Yuliang Zhao,Yuliang Zhao +14 more
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TLDR
Improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo as a consequence of PVP‐Bi2Se3@Sec NPs treatment.Abstract:
The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2 Se3 nanoparicles (PVP-Bi2 Se3 @Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2 Se3 @Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2 Se3 @Sec NPs during the treatment, which demonstrates that PVP-Bi2 Se3 @Sec NPs have good biocompatibility.read more
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Reconstruction of nano-flares based on Au–Se bonds for high-fidelity detection of RNA in living cells
TL;DR: A Au-Se-DNA nanoprobe is developed by upgrading the conventional Au-S bonds of nano-flares to more stable Au- Se bonds for high-fidelity imaging of target RNAs in living cells.
Journal ArticleDOI
Fabrication of PEGylated Bi2S3 Nanosheets As a Multifunctional Platform for Multimodal Diagnosis and Combination Therapy for Cancer
TL;DR: 2D Bi2S3–PEG nanosheets are successfully synthesized in a rapid and environmentally friendly manner and were applied into tumor therapy and exhibit high photothermal conversion efficiency and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy.
Journal ArticleDOI
Gold-iron selenide nanocomposites for amplified tumor oxidative stress-augmented photo-radiotherapy.
Jingsong Lu,Zhenhu Guo,Wensheng Xie,Yongjie Chi,Junxin Zhang,Wanling Xu,Xiaoxiao Guo,Jielin Ye,Yen Wei,Hong Wu,Jing Yu,Yu-Fen Huang,Lingyun Zhao +12 more
TL;DR: Polyethylene glycol-modified gold-iron selenide nanocomposites (Au-FeSe2 NCs) are investigated for simultaneously enhancing therapeutic effects in multiple ways and could exhibit a remarkable RT/PTT synergistic effect on tumor treatment.
Journal ArticleDOI
Transformable Gallium‐Based Liquid Metal Nanoparticles for Tumor Radiotherapy Sensitization
Ruixue Liu,Linji Gong,Xiangdong Zhu,Shuang Mei Zhu,Xiaochen Wu,Tingyu Xue,Liang Yan,Jiangfeng Du,Zhanjun Gu +8 more
TL;DR: In this paper , the authors used nanosized gallium-indium eutectic alloys (EGaIn) as a radiosensitizer for enhancing tumor radiotherapy.
Journal ArticleDOI
Size-controlled synthesis of hierarchical bismuth selenide nanoflowers and their photocatalytic performance in the presence of H 2 O 2
Dong Li,Minjie Fang,Chunli Jiang,Hechun Lin,Chunhua Luo,Ruijuan Qi,Rong Huang,Hui Peng,Hui Peng +8 more
TL;DR: In this article, size-controllable Bi2Se3 nanoflowers (NFs) composed of numerous thin nanosheets are successfully synthesized by a hot-solution injection method under mild conditions.
References
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Journal ArticleDOI
The importance of selenium to human health
TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
The importance of selenium to human health.
TL;DR: The essential trace mineral, selenium, is of fundamental importance to human health as mentioned in this paper, and it is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
Journal ArticleDOI
Oxidative DNA damage: mechanisms, mutation, and disease
TL;DR: This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
Journal ArticleDOI
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.