Journal ArticleDOI
Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
Jiangfeng Du,Jiangfeng Du,Zhanjun Gu,Liang Yan,Yuan Yong,Xuan Yi,Xiao Zhang,Jing Liu,Renfei Wu,Cuicui Ge,Chunying Chen,Chunying Chen,Chunying Chen,Yuliang Zhao,Yuliang Zhao +14 more
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TLDR
Improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo as a consequence of PVP‐Bi2Se3@Sec NPs treatment.Abstract:
The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2 Se3 nanoparicles (PVP-Bi2 Se3 @Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2 Se3 @Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2 Se3 @Sec NPs during the treatment, which demonstrates that PVP-Bi2 Se3 @Sec NPs have good biocompatibility.read more
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Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment
Zhao Wang,Shili Gai,Chuanqing Wang,Guixin Yang,Chongna Zhong,Yunlu Dai,Fei He,Dan Yang,Piaoping Yang +8 more
TL;DR: The as-prepared ZnPc nanoparticles not only showed good stability, excellent biocompatibility, and absorption in the appropriate NIR region, but also exhibited high photothermal conversion efficiency and remarkable PDT performance, making them an ideal phototheranostic agent for effective and safe cancer treatment in clinical research.
Journal ArticleDOI
Effect of molecular weight of chitosan and its oligosaccharides on antitumor activities of chitosan-selenium nanoparticles.
TL;DR: Study of antitumor efficacy and side effect on a HepG2 xenograft BALB/c nude mice model exhibited that CS-Se0NPs had a higher selectivity for cancer cells; however, their effect on normal cells, which have relatively lower ROS levels, was limited.
Journal ArticleDOI
Stimuli-Responsive Small-on-Large Nanoradiosensitizer for Enhanced Tumor Penetration and Radiotherapy Sensitization.
Wenhui Fu,Wenhui Fu,Xiao Zhang,Linqiang Mei,Ruyi Zhou,Wenyan Yin,Qiang Wang,Qiang Wang,Zhanjun Gu,Yuliang Zhao +9 more
TL;DR: This TME-responsive precise nanoradiosensitization achieved improved irradiation effectiveness, potent oxygenation in tumor and efficient suppression to tumor, which can be real-time monitored by computed tomography (CT) and photoacoustic (PAT) imaging.
Journal ArticleDOI
Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers
Yu Fan,Wenzhi Tu,Mingwu Shen,Xuming Chen,Yuesheng Ning,Junjun Li,Tingfeng Chen,Han Wang,Fangfang Yin,Yong Liu,Xiangyang Shi +10 more
TL;DR: The creation of hypoxia‐targeted dendrimer‐entrapped gold nanoparticles complexed with gadolinium(III) (Gd‐Au DENPs‐Nit) for dual‐mode CT/MR imaging and sensitized RT of hypoxic tumors is reported.
Journal ArticleDOI
Simultaneously activating highly selective ratiometric MRI and synergistic therapy in response to intratumoral oxidability and acidity.
TL;DR: A novel doxorubicin (DOX)-loaded degradable cobalt oxide nanoprism (Co3O4-DOX) for T1/T2 ratiometric magnetic resonance imaging (MRI)-monitored synergistic cancer therapy that simultaneously responds to intratumoral oxidability and acidity is reported.
References
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
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The importance of selenium to human health
TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
The importance of selenium to human health.
TL;DR: The essential trace mineral, selenium, is of fundamental importance to human health as mentioned in this paper, and it is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
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Oxidative DNA damage: mechanisms, mutation, and disease
TL;DR: This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
Journal ArticleDOI
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.