Journal ArticleDOI
Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
Jiangfeng Du,Jiangfeng Du,Zhanjun Gu,Liang Yan,Yuan Yong,Xuan Yi,Xiao Zhang,Jing Liu,Renfei Wu,Cuicui Ge,Chunying Chen,Chunying Chen,Chunying Chen,Yuliang Zhao,Yuliang Zhao +14 more
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TLDR
Improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo as a consequence of PVP‐Bi2Se3@Sec NPs treatment.Abstract:
The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2 Se3 nanoparicles (PVP-Bi2 Se3 @Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2 Se3 @Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2 Se3 @Sec NPs during the treatment, which demonstrates that PVP-Bi2 Se3 @Sec NPs have good biocompatibility.read more
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Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer.
Tao Zhang,Bihan Wu,Ozioma Udochukwu Akakuru,Chenyang Yao,Shan Sun,Libin Chen,Wenzhi Ren,Aiguo Wu,Pintong Huang +8 more
TL;DR: In this paper, a novel photosensitizer with mitochondrial targeting based on IR780 iodide and heat shock protein 90 inhibitor (BIIB021), which can passively accumulate in MCF-7cells and achieve effective MT-PTT effect is synthesized.
Journal ArticleDOI
Naturally-Derived PHA-L Protein Nanoparticle as a Radioprotector Through Activation of Toll-Like Receptor 5.
Wei Long,Junying Wang,Jiang Yang,Hongying Wu,Jingya Wang,Xiaoyu Mu,Hua He,Qiang Liu,Yuan-Ming Sun,Haichao Wang,Xiaodong Zhang +10 more
TL;DR: A detailed study of the mechanism shows PHA-L protein nanoparticle can target and activate the toll-like receptor 5 in vitro and in vivo, and thus protect irradiated cells by immune response, and can perform highly efficient clearance while eliciting negligible toxicological response.
Journal ArticleDOI
Tumor‐Tropic Adipose‐Derived Mesenchymal Stromal Cell Mediated Bi2Se3 Nano‐Radiosensitizers Delivery for Targeted Radiotherapy of Non‐Small Cell Lung Cancer
TL;DR: The results reveal that the optimized intracellular loading strategy hardly affects cell viability, specific surface markers, or migration capability of AD‐MSCs, and Bi2Se3 NPs can be efficiently transported from AD‐ MSCs to tumor cells.
Journal ArticleDOI
Recent antioxidative nanomaterials toward wound dressing and disease treatment via ROS scavenging
TL;DR: A brief review of recent antioxidative nanomaterials and their specific design concepts are provided, unprecedentedly, categorized by their nanostructure dimensions as discussed by the authors , from zero dimension to three dimensions.
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External use of Nano-graphdiyne hydrogel for skin radioprotection via both physically shielding of Low-energy X-ray and chemically scavenging of Broad-spectrum free radicals
Priya Vinod,P. Ganga Raju Achary +1 more
TL;DR: Wang et al. as mentioned in this paper designed and synthesized nanosized graphdiyne-loaded sodium hyaluronate hydrogel, which possesses powerful broad-spectrum free radical scavenging activity by the nano-GDY and good low-energy X-ray attenuation ability by the hyrogel with high water content.
References
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
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The importance of selenium to human health
TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
The importance of selenium to human health.
TL;DR: The essential trace mineral, selenium, is of fundamental importance to human health as mentioned in this paper, and it is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
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Oxidative DNA damage: mechanisms, mutation, and disease
TL;DR: This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
Journal ArticleDOI
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.