Journal ArticleDOI
Polycyclic indole alkaloid-type compounds by MCR
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TLDR
An efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction is communicated.About:
This article is published in Chemical Communications.The article was published on 2010-01-19. It has received 64 citations till now. The article focuses on the topics: Indole test & Indole alkaloid.read more
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Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
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Multicomponent reactions: advanced tools for sustainable organic synthesis
TL;DR: In this article, the utility of multicomponent reactions as methods for green synthesis is highlighted and the practical value of these type of reactions for meeting many of the criteria set by the green chemistry philosophy.
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Tetrazoles via Multicomponent Reactions.
TL;DR: The use of multicomponent reactions for the preparation of substituted tetrazole derivatives is reviewed and synthetic approaches and their value are discussed by analyzing scope and limitations, and also enlighten their receptor binding mode.
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To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis
Mariateresa Giustiniano,Andrea Basso,Valentina Mercalli,Alberto Massarotti,Ettore Novellino,Gian Cesare Tron,Jieping Zhu +6 more
TL;DR: All the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isOCyano group are reviewed and categorized to highlight their common features and differences.
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
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Über die Bildung von Isochinolin‐derivaten durch Einwirkung von Methylal auf Phenyl‐äthylamin, Phenyl‐alanin und Tyrosin
Amé Pictet,Theod. Spengler +1 more
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The Recent Impact of Solid-Phase Synthesis on Medicinally Relevant Benzoannelated Nitrogen Heterocycles
TL;DR: In this review, a number of synthetic strategies for the generation of benzoannelated nitrogen heterocycles using resin-bound substrates have been described and particular emphasis has been focused on the synthesis of libraries and the use of combinatorial chemistry techniques.
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Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
TL;DR: Orexin/hypocretin neuropeptides are peptides discovered and published in 1998 by two independent research groups as the outcome of methodical deorphanization programs focusing on brain orphan G-protein-coupled receptors (GPCR).
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One-pot synthesis and biological evaluation of aspergillamides and analogues.
TL;DR: A one-pot total synthesis of aspergillamide and analogues by a solution phase Ugi multi component reaction (MCR) is described and the antibiotic and cytotoxic activity of these compounds is measured.