Journal ArticleDOI
Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
TLDR
In conclusion, polydatin effectively inhibited hypoxia- and AMI-induced myocardial damage by promotion of Nrf2/HO-1 signaling.Abstract:
Polydatin is a traditional Chinese medicine that provides myocardial protection after acute myocardial infarction (AMI) The study aim was to investigate the myocardial protection polydatin in H9c2 myocardial cells cultured in a hypoxic atmosphere and in a rat AMI model induced by ligating the left anterior descending coronary artery and treated with polydatin 100 mg/kg/day for 30 days The involvement of Nrf2 in mediating the effects of polydatin was investigated in H9c2 cells following Nrf2 knockdown by transfection of siRNA Polydatin suppressed hypoxia-induced H9c2 cell apoptosis and reactive oxygen species (ROS) generation by promoting Nrf2/HO-1 signaling Nrf2 knockdown reversed the protective effects of polydatin against hypoxia-induced myocardial cell injury The in vivo results were consistent with polydatin suppression of apoptosis and ROS generation in myocardial tissue by promotion of Nrf2/HO-1 signaling In conclusion, polydatin effectively inhibited hypoxia- and AMI-induced myocardial damage by promotion of Nrf2/HO-1 signalingread more
Citations
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Journal ArticleDOI
Efficiency of Traditional Chinese medicine targeting the Nrf2/HO-1 signaling pathway.
Bin Li,M.I. Nasser,Muqaddas Masood,Salah Adlat,Yufei Huang,Baoling Yang,Chaochao Luo,Nan Jiang +7 more
TL;DR: This analysis summarized the relationship between Nrf2/HO-1 signaling route, CVD and TCM and found that TCM has important multi-target, multi-pathway, and multi-layer benefits that can effectively address western medicine deficiencies.
Journal ArticleDOI
Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice.
Meili Wang,Die Pu,Yuxing Zhao,Jinliang Chen,Shiyu Zhu,Ankang Lu,Zhilin Liao,Yue Sun,Qian Xiao +8 more
TL;DR: It is demonstrated that SFN can protect against skeletal muscle diseases in db/db type 2 diabetic mice and provide a potential drug to prevent skeletal muscle dysfunction in T2DM patients.
Journal ArticleDOI
Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats
TL;DR: In this article, the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs) and metformin (MET) on diabetic cardiomyopathy in rats was investigated.
Journal ArticleDOI
Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis
TL;DR: The overall results indicate that the combination of inclusion complexes with dissolving microneedles provides a potential route for treatment of acute gout arthritis by enhanced transdermal delivery of polydatin.
Journal ArticleDOI
Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits
TL;DR: The therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers and the need to develop further clinical trials and novel delivery systems is considered.
References
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Journal ArticleDOI
Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease.
Tahir Ali,Tae Hyun Kim,Shafiq Ur Rehman,Muhammad Sohail Khan,Faiz Ul Amin,Mehtab Khan,Muhammad Ikram,Myeong Ok Kim +7 more
TL;DR: It is suggested that consumption and supplementation of natural-derived anti-oxidant neuroprotective agent such as anthocyanins may be beneficial and suggest new dietary-supplement strategies for intervention in and prevention of progressive neurodegenerative diseases, such as AD.
Journal ArticleDOI
Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway.
Ying Xin,Yang Bai,Xin Jiang,Shanshan Zhou,Yuehui Wang,Kupper A. Wintergerst,Taixing Cui,Honglei Ji,Yi Tan,Yi Tan,Lu Cai +10 more
TL;DR: SFN prevents Ang II-induced cardiomyopathy partially via the Akt/GSK-3β/Fyn-mediated Nrf2 activation, and NRF2 plays a central role in the prevention.
Journal ArticleDOI
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Mingcai Liang,Zhengxuan Wang,Hui Li,Liang Cai,Jianghao Pan,Hongjuan He,Qiong Wu,Yinzhao Tang,Jiapei Ma,Lin Yang +9 more
TL;DR: The present study demonstrates that the supplementation of l-arginine stimulates GSH synthesis and activates Nrf2 pathway, leading to the up-regulation of ARE-driven antioxidant expressions via NRF2-Keap1 pathway, indicating an upward trend in antioxidant capacity uniformly with the increasing consumption ofl-argInine.
Journal ArticleDOI
Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway
Dandan Han,Wei Chen,Xiaolong Gu,Ruixue Shan,Jiaqi Zou,Gang Liu,Muhammad Shahid,Jian Gao,Bo Han +8 more
TL;DR: It is demonstrated that CGA protected MC3T3-E1 cells against oxidative damage via PI3K/Akt-mediated activation of Nrf2/HO-1 pathway, which may be an effective drug in treatment of osteoporosis.
Journal ArticleDOI
Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.
Yoon-Jin Lee,Hyang-Yun Jeong,Yong Bae Kim,Yong-Jin Lee,Seong Youn Won,Jung-Hyun Shim,Moon-Kyun Cho,Hae-Seon Nam,Sang-Han Lee +8 more
TL;DR: The results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane-treated MSTO-211H cells.