Journal ArticleDOI
Polyene Macrolide Antibotic Derivatives: Preparation, Overcoming Drug Resistance, and Prospects for Use in Medical Practice (Review)
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TLDR
In this paper, a series of semi-synthetic polyene macrolide antibiotics (PMAs) that were prepared by chemical modification in original research by the authors are reviewed.Abstract:
Series of semi-synthetic polyene macrolide antibiotics (PMAs) that were prepared by chemical modification in original research by the authors are reviewed. Chemical modification, in particular phosphorylation, was shown to produce highly efficacious PMAs with low toxicities and extended spectra of biological activity. The prospects of using liposomal and nano-derivatives of these antifungal antibiotics are discussed. Crucial issues related to the resistance of pathogenic fungi and the expanding distribution of invasive mycoses are identified. Semi-synthetic PMAs are shown to be highly effective at preventing and treating invasive mycoses and opportunistic fungal infections occurring in AIDS patients. Special attention is paid to structure—activity relationships for the semi-synthetic PMAs. Possible mechanisms of action of these compounds on pathogenic fungi are discussed. An automated intellectual information system was developed for selecting the optimal conditions for development, synthesis, and application in medical practice of new PMAs.read more
Citations
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Advances in Planar Lipid Bilayers and Liposomes
Nicolae Goga,Andrzej J. Rzepiela,de Manuel Sousa Pereira Simoes de Melo,de Alex Vries,Anton Hadar,Albert J. Markvoort,SV Silvia Nedea,Herman J. C. Berendsen +7 more
Journal ArticleDOI
Oxidation, Coordination and Nickel‐Mediated Deconstruction of a Highly Electron‐Rich Diboron Analogue of 1,3,5‐Hexatriene
Alexander Hermann,Felipe Fantuzzi,Merle Arrowsmith,Theresa Zorn,Ivo Krummenacher,Benedikt Ritschel,Krzysztof Radacki,Bernd Engels,Holger Braunschweig +8 more
TL;DR: The reductive coupling of an N‐heterocyclic carbene (NHC) stabilized (dibromo)vinylborane yields a 1,2‐divinyldiborene, which, although isoelectronic to a 1‐3,5‐triene, displays no extended π conjugation because of twisting of the C2B2C2 chain.
Journal ArticleDOI
Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications
Tammy Haro-Reyes,Lucero Díaz‐Peralta,Arturo Galván-Hernández,Anahí Rodríguez-López,Lourdes Rodríguez-Fragoso,Iván Ortega-Blake +5 more
TL;DR: In this paper , a review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions, where membrane properties played a crucial role.
Journal ArticleDOI
Genome-Guided Discovery of Antifungal Filipins from a Deep-Sea-Derived Streptomyces antibioticus.
TL;DR: Nine new and three known filipin-type polyene macrolides were isolated from the deep-sea-derived Streptomyces antibioticus OUCT16-23 using a genome-guided strategy coupled with bioassay and their structures were elucidated based on the extensive MS and NMR spectroscopic analyses together with ECD calculations.
Proceedings ArticleDOI
A Computer System for Predicting Antimycotic Properties
TL;DR: A computer system for predicting antimycotic properties, which can predict a certain compound’s toxicity and useful properties based on its chemical structure, as well as find similar synthesis parameters from a compound synthesis methods database, is discussed.
References
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