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Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells.

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TLDR
Interactions between neural cells and the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) toward development of electrically conductive biomaterials intended for direct, functional contact with electrically active tissues such as the nervous system, heart, and skeletal muscle are described.
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This article is published in Biomaterials.The article was published on 2007-03-01 and is currently open access. It has received 471 citations till now. The article focuses on the topics: Poly(3,4-ethylenedioxythiophene) & PEDOT:PSS.

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Citations
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Journal ArticleDOI

Neural stimulation and recording electrodes.

TL;DR: Techniques for characterizing electrochemical properties relevant to stimulation and recording are described with examples of differences in the in vitro and in vivo response of electrodes.
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Conducting polymers in biomedical engineering

TL;DR: Although there remain many unanswered questions, particularly regarding the mechanisms by which electrical conduction through CPs affects cells, there is already compelling evidence to demonstrate the significant impact that CPs are starting to make in the biomedical field.
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Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering.

TL;DR: By taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering.
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Conductive Polymers: Opportunities and Challenges in Biomedical Applications

TL;DR: This review seeks to describe the chemical forms and functionalities of the main types of conductive polymers, as well as their synthesis methods, and expound on the plethora of biomedical applications that harbor the potential to be revolutionized by conductivepolymers.
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Nanomaterials for Neural Interfaces

TL;DR: This review focuses on the application of nanomaterials for neural interfacing, covering a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfaced, and photoactivated interfaces.
References
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Journal ArticleDOI

Response of brain tissue to chronically implanted neural electrodes.

TL;DR: This review presents the biological components and time course of the acute and chronic tissue reaction in brain tissue, analyses the brain tissue response of current electrode systems, and comments on the various material science and bioactive strategies undertaken by electrode designers to enhance electrode performance.
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Stimulation of neurite outgrowth using an electrically conducting polymer

TL;DR: The electrically conductive polymer--oxidized polypyrrole (PP)--has been evaluated for use as a substrate to enhance nerve cell interactions in culture as a first step toward potentially using such polymers to stimulate in vivo nerve regeneration.
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Adhesion-dependent cell mechanosensitivity.

TL;DR: This review discusses the structure-function relationships of focal adhesions and the possible mode of action of the putative mechanosensor associated with them, the general phenomenon of mechanosensitivity, and the approaches used to measure local forces at adhesion sites.
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Apoptosis and caspases in neurodegenerative diseases.

TL;DR: Pharmacologic interference with the induction or completion of apoptosis holds promise for the treatment of neurodegenerative diseases, and clinical trials with one such agent are already under way.
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Conducting‐Polymer Nanotubes for Controlled Drug Release

TL;DR: A method to prepare conducting-polymer nanotubes that can be used for precisely controlled drug release and significantly decrease the impedance and increase the charge capacity of the recording electrode sites on microfabricated neural prosthetic devices is reported on.
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