Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering.
Laleh Ghasemi-Mobarakeh,Molamma P. Prabhakaran,Mohammad Morshed,Mohammad Hossein Nasr-Esfahani,Hossein Baharvand,Sahar Kiani,Salem S. Al-Deyab,Seeram Ramakrishna,Seeram Ramakrishna +8 more
TLDR
By taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering.Abstract:
Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(e-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.read more
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Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Conductive polymers: towards a smart biomaterial for tissue engineering.
TL;DR: Focusing mainly on polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene), this work reviews conductive polymers from the perspective of tissue engineering.
Journal ArticleDOI
Electrically conductive polymers and composites for biomedical applications
TL;DR: A review of the recent investigations conducted in the development of conductive polymer composites focussing on the methods of their preparation, underlying concepts of their conductivity and the ways to tailor their properties is also discussed as mentioned in this paper.
Journal ArticleDOI
Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells
Ning Li,Qi Zhang,Song Gao,Qin Song,Rong Huang,Long Wang,Liwei Liu,Jianwu Dai,Mingliang Tang,Guosheng Cheng +9 more
TL;DR: Graphene foam, a 3D porous structure, is used as a novel scaffold for NSCs in vitro and phenotypic analysis indicated that 3D-GFs can enhance the NSC differentiation towards astrocytes and especially neurons.
Journal ArticleDOI
Biodegradable and electrically conducting polymers for biomedical applications
TL;DR: Conducting polymers have been widely used in biomedical applications such as biosensors and tissue engineering but their non-degradability still poses a limitation.
References
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Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
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