Journal ArticleDOI
Polystyrene‐supported AICI3: A highly active and reusable heterogeneous catalyst for the one‐pot synthesis of dihydropyrimidinones
Liang Wang,Chun Cai +1 more
TLDR
An environmentally benign Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrene supported aluminium chloride as catalyst has been achieved as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-11-01. It has received 30 citations till now. The article focuses on the topics: Aluminium chloride.read more
Citations
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Molecular iodine-catalyzed multicomponent reactions: an efficient catalyst for organic synthesis
TL;DR: The synergistic effect of the combined use of MCRs and molecular iodine for the development of new eco-compatible methodologies for organic chemistry is highlighted.
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Iodine-catalyzed transformation of molecules containing oxygen functional groups
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Preparation and characterization of bentonite/PS-SO3H nanocomposites as an efficient acid catalyst for the Biginelli reaction
TL;DR: In this paper, a bentonite/PS-SO3H nanocomposite was used as an acid catalyst for the Biginelli reaction under solvent-free conditions, which showed high thermal stability, good reusability and was environmentally benign.
Journal ArticleDOI
Biginelli Reaction: A Green Perspective
TL;DR: The Biginelli reaction is a one-pot acid catalysed cyclocondensation of keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalised 3,4-dihydro-2(H)-pyrimidinones (DHPMs) as mentioned in this paper.
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Biginelli Reaction: Polymer Supported Catalytic Approaches.
TL;DR: The present Review highlights the role of polymer-supported catalysts in Biginelli reaction, which may involve organic, inorganic, or hybrid polymers as support for catalysts.
References
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Journal ArticleDOI
Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.
TL;DR: This review highlights recent developments in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones with a focus on the DHPMs recently developed as calcium channel modulators, alpha(1a) adrenoceptor-selective antagonists and compounds that target the mitotic machinery.
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Preparation of polymer-supported ligands and metal complexes for use in catalysis.
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Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
Steven V. Ley,Ian R. Baxendale,Robert N. Bream,Philip S. Jackson,Andrew G. Leach,Deborah A. Longbottom,Marcella Nesi,James S. Scott,R. Ian Storer,Stephen Taylor +9 more
TL;DR: A review of solid-phase organic synthesis can be found in this article, where the authors discuss the use of reagents and scavenging reagents in the context of solid phase organic synthesis (SPOS).
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Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
TL;DR: Biginelli's initial one-pot reflux of â-keto ester 2, aryl aldehyde 3, and urea, 4, with catalytic acid in a protic solvent frequently afforded low (20-50%) yields as mentioned in this paper.