Journal ArticleDOI
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
TLDR
Postmortem studies in major depression and bipolar disorder provide the first evidence for specific neuronal and glial histopathology in mood disorders and a link between cellular changes and the action of therapeutic drugs is discussed.About:
This article is published in Biological Psychiatry.The article was published on 2000-10-15. It has received 799 citations till now. The article focuses on the topics: Mood disorders & Prefrontal cortex.read more
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
Journal ArticleDOI
Major depressive disorder.
Robert H. Belmaker,Galila Agam +1 more
TL;DR: This review presents the major current approaches to understanding the biologic mechanisms of major depression and defines depression as a heterogeneous disorder with a highly variable course, an inconsistent response to treatment, and no established mechanism.
Journal ArticleDOI
The brain reward circuitry in mood disorders
Scott J. Russo,Eric J. Nestler +1 more
TL;DR: This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression, and discusses some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
Journal ArticleDOI
Neuroimaging studies of mood disorders.
TL;DR: Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders.
References
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Principles of Neural Science
TL;DR: The principles of neural science as mentioned in this paper have been used in neural networks for the purpose of neural network engineering and neural networks have been applied in the field of neural networks, such as:
Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Book
The prefrontal cortex
TL;DR: The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain.
Journal ArticleDOI
Subgenual prefrontal cortex abnormalities in mood disorders
Wayne C. Drevets,Joseph L. Price,Joseph R. Simpson,Richard D. Todd,Theodore Reich,Michael W. Vannier,Michael W. Vannier,Marcus E. Raichle +7 more
TL;DR: Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.