Postprandial Hyperglycemia Lowering Effect of the Isolated Compounds from Olive Mill Wastes - An Inhibitory Activity and Kinetics Studies on α-Glucosidase and α-Amylase Enzymes.
Rogers Mwakalukwa,Rogers Mwakalukwa,Yhiya Amen,Yhiya Amen,Maki Nagata,Kuniyoshi Shimizu +5 more
- Vol. 5, Iss: 32, pp 20070-20079
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TLDR
Seven compounds from olive mill wastes are isolated and investigated their antidiabetic potential through inhibition of α-glucosidase and α-amylase enzymes, one of them being novel, and it is shown that the esterification of C-1 of the furofuran ring is the key feature for the stronger activity of 1-acetoxypinoresinol 3 against both enzymes.Abstract:
In the present study, we isolated seven compounds from olive mill wastes (OMW), one of them being novel, and investigated their antidiabetic potential through inhibition of α-glucosidase and α-amyl...read more
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The effects of Syzygium aromaticum derived oleanolic acid on glycogenic enzymes in streptozotocin induced-diabetic rats
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Applications of by-products from the olive oil processing: revalorization strategies based on target molecules and green extraction technologies
Paz Otero,Paula Garcia-Oliveira,Paula Garcia-Oliveira,Maria Carpena,M. Barral-Martinez,Franklin Chamorro,Javier Echave,Pascual García-Pérez,Hui Cao,Jianbo Xiao,Jianbo Xiao,Jesus Simal-Gandara,Miguel A. Prieto,Miguel A. Prieto +13 more
TL;DR: In this article, a review of the advances achieved to date in the olive oil by-products valorization focusing on their biological properties, including cardioprotective, antioxidant, anticancer, anti-inflammatory and antidiabetic effects, is presented.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems
TL;DR: Kinetics of Unireactant Enzymes.
Journal ArticleDOI
13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features
Shashi B. Mahato,Asish P. Kundu +1 more
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.
Journal ArticleDOI
Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.
TL;DR: Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
Journal ArticleDOI
Effect of Noninsulin Antidiabetic Drugs Added to Metformin Therapy on Glycemic Control, Weight Gain, and Hypoglycemia in Type 2 Diabetes
TL;DR: When added to maximal metformin therapy, all noninsulin antidiabetic drugs were associated with similar HbA(1c) reductions but differed in their associations with weight gain and risk of hypoglycemia.