Journal ArticleDOI
Potential blood biomarkers in chronic spontaneous urticaria.
TLDR
10 biomarkers are identified that are supported by strong evidence for distinguishing patients with CSU from healthy controls, or for measuring CSU activity, and there is a need for further research to identify biomarkers that predict outcome or treatment response in CSU.Abstract:
Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that is defined as the recurrence of weals, angioedema or both for > 6 weeks due to known or unknown causes. As of yet, disease diagnosis is purely clinical. Objective tools are needed to monitor the activity of CSU and the efficacy of treatment. Recently, several reports have suggested that blood parameters may be considered as potential disease-related biomarkers. Here, we reviewed available literature on blood biomarkers for CSU diagnosis, activity monitoring, duration, patient subgroup allocation or response to treatment. We performed a PubMed, Google Scholar and Web of Science search and identified and analysed 151 reports published prior to January 2016. We found strong evidence for significant differences between patients with CSU and healthy controls in blood levels or values of D-dimer, C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), mean platelet volume (MPV), factor VIIa, prothrombin fragment 1 + 2 (F1 + 2), tumour necrosis factor, dehydroepiandrosterone sulphate and vitamin D. Also, there is strong evidence for a significant association between CSU activity and blood levels or values of D-dimer, F1 + 2, CRP, IL-6 and MPV. Strong evidence for reduced basophil count and high levels of IgG anti-FceRI in the subgroup of CSU patients with positive autologous serum skin test was shown. In contrast, the evidence for all reported blood biomarkers for differentiating CSU from other diseases, or a role in prognosis, is weak, inconsistent or non-existent. Taken together, we identified 10 biomarkers that are supported by strong evidence for distinguishing patients with CSU from healthy controls, or for measuring CSU activity. There is a need for further research to identify biomarkers that predict outcome or treatment response in CSU.read more
Citations
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Journal ArticleDOI
The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria.
Torsten Zuberbier,Werner Aberer,Riccardo Asero,A H Abdul Latiff,Diane Baker,Barbara Ballmer-Weber,Jonathan A. Bernstein,Carsten Bindslev-Jensen,Zenon Brzoza,R Buense Bedrikow,G.W. Canonica,Martin K. Church,Timothy J. Craig,I V Danilycheva,Corinna Dressler,Luis Felipe Ensina,Ana Giménez-Arnau,Kiran Godse,Margarida Gonçalo,Clive Grattan,Jacques Hébert,Michihiro Hide,Allen P. Kaplan,Alexander Kapp,C. Katelaris,Emek Kocatürk,Kanokvalai Kulthanan,D. Larenas-Linnemann,Tabi A. Leslie,Markus Magerl,P. Mathelier-Fusade,R. Y. Meshkova,Martin Metz,Alexander Nast,Eustachio Nettis,Hanneke Oude-Elberink,Stefanie Rosumeck,Sarbjit S. Saini,Mario Sánchez-Borges,Peter Schmid-Grendelmeier,Petra Staubach,Gordon Sussman,Elias Toubi,Gino A. Vena,Christian Vestergaard,Bettina Wedi,Ricardo Niklas Werner,Zuotao Zhao,Marcus Maurer +48 more
TL;DR: In this paper, an evidence-and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group.
Journal ArticleDOI
IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria
Oliver Schmetzer,Elisa Lakin,Fatih A Topal,Patricia Preusse,Denise Freier,Martin K. Church,Marcus Maurer +6 more
TL;DR: In this article, the efficacy of omalizumab (anti-IgE) and increased IgE levels in patients with chronic spontaneous urticaria suggest autoallergic mechanisms.
Journal ArticleDOI
Evaluating Comorbidities, Natural History, and Predictors of Early Resolution in a Cohort of Children With Chronic Urticaria
Elena Netchiporouk,Denis Sasseville,Linda Moreau,Youssef Habel,Elham Rahme,Moshe Ben-Shoshan +5 more
TL;DR: Resolution rate in children with CU is low, but the presence of certain biomarkers (positive BAT result and basophil count) may help to predict the likelihood of resolution.
Journal ArticleDOI
C‐reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria
TL;DR: retrospectively analyzed data from 1253 CSU patients from 2 centers to answer the following questions: (i) What is the prevalence of elevated levels of CRP in CSU? (ii) Why doCSU patients show elevated levelsof CRP? (iii) Are elevated CRP levels relevant?
Journal ArticleDOI
Corticosteroids in management of anaphylaxis; a systematic review of evidence.
TL;DR: It is concluded that there is no compelling evidence to support or oppose the use of corticosteroid in emergency treatment of anaphylaxis, and based on the available data, it appears to be beneficial and there was no evidence of adverse outcomes related to the use.
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Journal ArticleDOI
The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update.
Torsten Zuberbier,Werner Aberer,Riccardo Asero,Carsten Bindslev-Jensen,Zenon Brzoza,Giorgio Walter Canonica,Martin K. Church,Luis Felipe Ensina,Ana Giménez-Arnau,Kiran Godse,Margarida Gonçalo,Clive Grattan,Jacques Hébert,Michihiro Hide,Allen P. Kaplan,Alexander Kapp,A H Abdul Latiff,P. Mathelier-Fusade,Martin Metz,Alexander Nast,Sarbjit S. Saini,Mario Sánchez-Borges,Peter Schmid-Grendelmeier,F. E. R. Simons,Petra Staubach,Gordon Sussman,Elias Toubi,Gino A. Vena,Bettina Wedi,X J Zhu,Markus Maurer +30 more
TL;DR: This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms, and outlines evidence-based diagnostic and therapeutic approaches for the different subtypes ofUrticaria.
Journal ArticleDOI
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.
Marcus Maurer,Karsten Weller,Carsten Bindslev-Jensen,Ana Giménez-Arnau,P. J. Bousquet,Jean Bousquet,G.W. Canonica,M. K. Church,M. K. Church,Kiran Godse,Clive Grattan,Malcolm W. Greaves,Michihiro Hide,Dimitris Kalogeromitros,Allen P. Kaplan,Sarbjit S. Saini,X J Zhu,T. Zuberbier +17 more
TL;DR: A GA2LEN task force report concluded that chronic spontaneous urticaria is a “hidden epidemic” that needs to be addressed to address the unmet clinical needs of patients.
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Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.
The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update.
Torsten Zuberbier,Werner Aberer,Riccardo Asero,Carsten Bindslev-Jensen,Zenon Brzoza,Giorgio Walter Canonica,Martin K. Church,Luis Felipe Ensina,Ana Giménez-Arnau,Kiran Godse,Margarida Gonçalo,Clive Grattan,Jacques Hébert,Michihiro Hide,Allen P. Kaplan,Alexander Kapp,A H Abdul Latiff,P. Mathelier-Fusade,Martin Metz,Alexander Nast,Sarbjit S. Saini,Mario Sánchez-Borges,Peter Schmid-Grendelmeier,F. E. R. Simons,Petra Staubach,Gordon Sussman,Elias Toubi,Gino A. Vena,Bettina Wedi,X J Zhu,Markus Maurer +30 more
The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria.
Torsten Zuberbier,Werner Aberer,Riccardo Asero,A H Abdul Latiff,Diane Baker,Barbara Ballmer-Weber,Jonathan A. Bernstein,Carsten Bindslev-Jensen,Zenon Brzoza,R Buense Bedrikow,G.W. Canonica,Martin K. Church,Timothy J. Craig,I V Danilycheva,Corinna Dressler,Luis Felipe Ensina,Ana Giménez-Arnau,Kiran Godse,Margarida Gonçalo,Clive Grattan,Jacques Hébert,Michihiro Hide,Allen P. Kaplan,Alexander Kapp,C. Katelaris,Emek Kocatürk,Kanokvalai Kulthanan,D. Larenas-Linnemann,Tabi A. Leslie,Markus Magerl,P. Mathelier-Fusade,R. Y. Meshkova,Martin Metz,Alexander Nast,Eustachio Nettis,Hanneke Oude-Elberink,Stefanie Rosumeck,Sarbjit S. Saini,Mario Sánchez-Borges,Peter Schmid-Grendelmeier,Petra Staubach,Gordon Sussman,Elias Toubi,Gino A. Vena,Christian Vestergaard,Bettina Wedi,Ricardo Niklas Werner,Zuotao Zhao,Marcus Maurer +48 more