Potentiation of antimicrobial photodynamic inactivation by inorganic salts.
Reads0
Chats0
TLDR
The addition of iodide has been shown to improve the performance of aPDT in several animal models of localized infection, and KI is non-toxic and is an approved drug for antifungal therapy, so its transition to clinical use in aPDt should be straightforward.Abstract:
Introduction: Antimicrobial photodynamic inactivation (aPDI) involves the use of non-toxic dyes excited with visible light to produce reactive oxygen species (ROS) that can destroy all classes of microorganisms including bacteria, fungi, parasites, and viruses. Selectivity of killing microbes over host mammalian cells allows this approach (antimicrobial photodynamic therapy, aPDT) to be used in vivo as an alternative therapeutic approach for localized infections especially those that are drug-resistant.Areas covered: We have discovered that aPDI can be potentiated (up to 6 logs of extra killing) by the addition of simple inorganic salts. The most powerful and versatile salt is potassium iodide, but potassium bromide, sodium thiocyanate, sodium azide and sodium nitrite also show potentiation. The mechanism of potentiation with iodide is likely to be singlet oxygen addition to iodide to form iodine radicals, hydrogen peroxide and molecular iodine. Another mechanism involves two-electron oxidation of...read more
Citations
More filters
Journal ArticleDOI
Antimicrobial photodynamic therapy – what we know and what we don’t
Fabian Cieplik,Dongmei Deng,Wim Crielaard,Wolfgang Buchalla,Elmar Hellwig,Ali Al-Ahmad,Tim Maisch +6 more
TL;DR: A review of the history of the antimicrobial photodynamic therapy (aPDT), its fundamental photochemical and photophysical mechanisms as well as photosensitizers and light sources that are currently applied for aPDT in vitro and implications for proper comparison of in vitro studies regarding a PDT are given.
Journal ArticleDOI
Trends and targets in antiviral phototherapy
TL;DR: This review focuses on the PDI of viruses as an alternative treatment in antiviral therapy, but also as a means of viral decontamination, covering mainly the literature of the last decade.
Journal ArticleDOI
Fullerenes as photosensitizers in photodynamic therapy: pros and cons.
TL;DR: A series of functionalized fullerenes with attached polycationic chains and additional light-harvesting antennae that can be used in vitro and in animal models of localized infections, suggesting a possible role of fullerene in photodynamic therapy (PDT).
Journal ArticleDOI
An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy.
Cátia Vieira,Ana T. P. C. Gomes,Mariana Q. Mesquita,Nuno M. M. Moura,M. Graça P. M. S. Neves,M. Amparo F. Faustino,Adelaide Almeida +6 more
TL;DR: The results indicate that KI has also the ability to potentiate the aPDT process mediated by some of the cationic PSs allowing a drastic reduction of the treatment time as well as of the PS concentration.
Journal ArticleDOI
Can light-based approaches overcome antimicrobial resistance?
TL;DR: Evidence is gained that all these approaches can kill multidrug resistant bacteria in vitro, and they do not induce themselves any resistance, and moreover can treat animal models of localized infections caused by resistant species that can be monitored by noninvasive bioluminescence imaging.
References
More filters
Journal ArticleDOI
Photodynamic therapy of cancer: An update†‡
Patrizia Agostinis,Kristian Berg,Keith A. Cengel,Thomas H. Foster,Albert W. Girotti,Sandra O. Gollnick,Stephen M. Hahn,Michael R. Hamblin,Michael R. Hamblin,Asta Juzeniene,David Kessel,Mladen Korbelik,Johan Emelian Moan,Johan Emelian Moan,Pawel Mroz,Dominika Nowis,Jacques Piette,Brian C. Wilson,Jakub Golab,Jakub Golab +19 more
TL;DR: The photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells as discussed by the authors, which can prolong survival in patients with inoperable cancers and significantly improve quality of life.
Journal Article
Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor
TL;DR: The protective effect against photodynamic inactivation of the TA-3 cells afforded by 1,3-diphenylisobenzofuran coupled with the nearly quantitative formation of the singlet oxygen-trapping product indicates that Singlet oxygen is the probable agent responsible for toxicity in this system.
Journal ArticleDOI
New photosensitizers for photodynamic therapy
TL;DR: The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery, and future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.
Journal ArticleDOI
Photophysical and photobiological processes in the photodynamic therapy of tumours
TL;DR: The purpose of this review article is to summarize the up-to-date knowledge on the mechanisms responsible for the induction of tumour necrotic reactions.
Journal ArticleDOI
Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes.
TL;DR: The microbial killing by aPDI can be synergistically potentiated by harmless inorganic salts via photochemistry, and genetically engineered bioluminescent microbial cells allow PDT to treat infections in animal models.