Pregnancy outcome after oocyte donation in patients with Turner's syndrome and partial X monosomy
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TLDR
Pregnancy rates after oocyte donation in patients with TS are comparable with those previously published but a high risk of pregnancy hypertensive disorders and a highrisk of low birthweight can be highlighted from this study.Abstract:
Background Fertility expectations for patients with Turner's syndrome (TS) have clearly changed in the last three decades. However, medical risks during pregnancy are supposed to be highly increased. The aim of the study was to assess clinical outcome and obstetrical complications in a series of patients with TS in an oocyte donor programme. Methods A retrospective study was carried out on 24 women with TS seeking a pregnancy in the Fertility Clinic of the Erasme Hospital from 1992 up until March 2011. Results Twenty-three patients with TS were included in an oocyte donation cycle. Forty-nine oocyte donation cycles were performed, which led to 45 fresh and 10 frozen-thawed embryo transfers. Altogether, 18 pregnancies were obtained, 10 deliveries (9 singletons and 1 pair of twins), 3 miscarriages and 5 biochemical pregnancies. The clinical pregnancy rate per transfer was 24.4% in fresh cycles and 20% in frozen replacement cycles. Complications of pregnancy occurred in 5 of 10 pregnancies (50%), which led to three premature deliveries because of pregnancy-induced hypertensive disorders. The mean birthweight (g) (±SD) for singletons and twins was 2728 ± 577 and 2335 ± 318, respectively. Four babies were below the 10th percentile. No cardiac complications were observed in any of the pregnant women. Conclusions Pregnancy rates after oocyte donation in patients with TS are comparable with those previously published but a high risk of pregnancy hypertensive disorders and a high risk of low birthweight can be highlighted from our study. Strict inclusion criteria and single embryo transfer are necessary to minimize complications during pregnancy in this high-risk group.read more
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Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting
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TL;DR: This study suggests that pregnancy outcomes in SPs are more favourable than those after oocyte donation in TS patients, however, the risk of fetal chromosomal abnormalities remains high.
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Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association.
Michael Silberbach,Jolien W. Roos-Hesselink,Niels Holmark Andersen,Alan C. Braverman,Nicole Brown,R. Thomas Collins,Julie De Backer,Kim A. Eagle,Loren F. Hiratzka,Walter H. Johnson,Daniella Kadian-Dodov,Leo Lopez,Kristian H. Mortensen,Siddharth K. Prakash,Elizabeth V Ratchford,Arwa Saidi,Iris M. van Hagen,Luciana T. Young +17 more
TL;DR: Suggestions for clinical practice stated here are only the beginning of a process that must also involve the establishment of quality indicators, structures and processes for implementation, and outcome studies.
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Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study
A. Hagman,Anne Loft,Ulla-Britt Wennerholm,Anja Pinborg,Christina Bergh,Kristiina Aittomäki,Karl-Gösta Nygren,Liv Bente Romundstad,Johan Hazekamp,Viveca Söderström-Anttila +9 more
TL;DR: This study suggests that cardiovascular evaluation before and during pregnancy may contribute to favourable obstetric outcomes in many cases, and maternal outcomes were in agreement with the literature while neonatal outcomes were generally better than previously reported.
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Journal ArticleDOI
A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome)
The Practice Committee of the American Society for Reproductive Medicine
TL;DR: This document reviews the scientific background, current technology, clinical results and potential future applications of two methods for preserving female fertility—ovarian tissue cryopreservation and oocyte cryopReservation.