Journal ArticleDOI
Preparation and characterization of chitosan-treated alginate microparticles incorporating all-trans retinoic acid.
A. A. M. Lira,Fábia Cristina Rossetti,Denise M. A. Nanclares,Alberto Federman Neto,Maria Vitória Lopes Badra Bentley,Juliana Maldonado Marchetti +5 more
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TLDR
The results of in vitro retention studies showed that chitosan treated alginate microparticles decreased the drug retention in the stratum corneum, but maintained the ATRA concentration in the deeper skin layers, where occur the pathologies treated with ATRA.Abstract:
Chitosan treated alginate microparticles were prepared with the purpose of incorporating all-trans retinoic acid (ATRA) using an inexpensive, simple and fast method, enhancing dermal localization and sustaining the release of ATRA into the skin. Microparticles characterization, drug-polymer interaction, release profile and in vitro skin retention were investigated. Microparticles presented spherical shape and drug loading capacity of 47%. The drug content of these microparticles was affected by ATRA concentration and by the solvent used and it was more weakly affected by chitosan concentration. The release of ATRA was also affected by chitosan concentration. Microparticles prepared with 0.4% chitosan (w/w) resulted in drug release with a more sustained profile. The results of in vitro retention studies showed that chitosan treated alginate microparticles decreased the drug retention in the stratum corneum (SC), where occur the skin irritation, but maintained the ATRA concentration in the deeper skin layers, where occur the pathologies treated with ATRA. Then, the microparticles developed in this work can be a good candidate to improve the topical therapy with retinoid.read more
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Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
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Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin.
Loreana Lacerda,Alexandre Luis Parize,Valfredo T. Fávere,Mauro C. M. Laranjeira,Hellen Karine Stulzer +4 more
TL;DR: The results obtained showed that the alginate/chitosan microparticles represent an efficient system for the controlled-release of RIF, and the dissolution efficiencies were similar for both formulations.
Journal ArticleDOI
Topical drug delivery using chitosan nano- and microparticles.
Ali Demir Sezer,Erdal Cevher +1 more
TL;DR: The advances that have been made, new strategies and as well as possible challenges of particular systems of chitosan used in topical drug delivery, including challenging innovations in topical usage of these systems that can make significant impact on clinical practice are described.
Journal ArticleDOI
Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study
Valquíria T. Arantes,André Augusto Gomes Faraco,Frederico B. Ferreira,Cleida A. Oliveira,Elisângela Martins-Santos,Puebla Cassini-Vieira,Lucíola S. Barcelos,Lucas Antônio Miranda Ferreira,Gisele Assis Castro Goulart +8 more
TL;DR: Results indicated that SLN-ATRA surrounded in chitosan films are a promising candidate to treat diabetic wounds, improving tissue healing and promoting wound healing in a diabetic mouse model.
Journal ArticleDOI
Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds
Andreea Barbu,Bogdan Neamtu,Marius Zahan,Gabriela Mariana Iancu,Ciprian Băcilă,Vioara Mireșan +5 more
TL;DR: In this article, the role of alginates in advanced wound-dressing forms with a particular emphasis on hydrogels, nanofibers networks, 3D-scaffolds or sponges entrapping fibroblasts, keratinocytes, or drugs to be released on the woundbed is explored.
References
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Journal ArticleDOI
Optimization of topical cidofovir penetration using microparticles.
TL;DR: Data showed that cidofovir-loaded microparticles could improve cid ofovir topical therapy since these vehicles increased drug retention in the basal epidermis and decreased its penetration through the skin.
Journal Article
The stability of tretinoin in tretinoin gel microsphere 0.1
TL;DR: The data suggest that the tretinoin gel microsphere 0.1% formulation offers marked protection against t retinoin photo degradation, even in the presence of a strong oxidizing agent such as benzoyl peroxide.
Journal ArticleDOI
A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E
Juliana Bucchi Alencastre,Maria Vitória Lopes Badra Bentley,F. S. Garcia,Maria de Moragas,Joseph Luis Viladot,Juliana Maldonado Marchetti +5 more
TL;DR: In this article, a set of precursors of carboximetilcelulose (CMC)/quitosana contendo vitamina E foram pre-processed pelo metodo de coacervacao complexa and seu uso potencial como um sistema de liberacao topico foi avaliado.
Journal ArticleDOI
Drug-polymer interaction in the all-trans retinoic acid release from chitosan microparticles
TL;DR: In this paper, Chitosan microparticles were prepared with the purpose of incorporating all-trans retinoic acid (ATRA), and the results of DSC and IR spectroscopy demonstrated interaction between drug and polymer resulting from retinoate or retinoamide formation.
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A comparative evaluation of tretinoin gel microsphere, 0.1%, versus tretinoin cream, 0.025%, in reducing facial shine.
TL;DR: Tretinoin gel microsphere, 0.1%, has the added benefit of reducing the appearance of facial shine, which is a frequent concern in acne patients, and was evaluated in a single-center, double-blind, half-face study.