Journal ArticleDOI
Preparation and in vitro characterization of cross-linked collagen–gelatin hydrogel using EDC/NHS for corneal tissue engineering applications
TLDR
Investigation of biocompatibility and physical properties of the bio-engineered cornea fabricated from type-I collagen (COL) and gelatin (Gel) suggests that incorporation of COL-I increases optical properties, hydrophilicity, stiffness and Young's modulus.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2019-04-01. It has received 111 citations till now. The article focuses on the topics: Self-healing hydrogels & Gelatin.read more
Citations
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3D printing of hydrogels: Rational design strategies and emerging biomedical applications
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
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Biopolymers for hydrogels in cosmetics: review.
TL;DR: Most common biopolymers used in cosmetics are presented in detail together with issues related to skin treatment and hair conditioning and new trends in the preparation of hydrogels based on biopolymer blends as well as bigels have been shown.
Journal ArticleDOI
Current methods of collagen cross-linking: Review.
TL;DR: The structure, preparation, and properties of several collagen based materials have been discussed in general, and detailed examples of collagen cross-linking methods have been drawn from scientific literature and practical work.
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Specialty Tough Hydrogels and Their Biomedical Applications
TL;DR: Several promising advances in the proposed use of specialty tough hydrogels for soft actuators, drug delivery vehicles, adhesives, coatings, and in tissue engineering settings are highlighted.
References
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Journal ArticleDOI
Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering.
TL;DR: Chondrocytes prefer the group of scaffolds with pore size between 250 and 500 microm for better proliferation and ECM production, and the size of the space for cell growth is a key factor for cell metabolism.
Journal ArticleDOI
Functional Human Corneal Equivalents Constructed from Cell Lines
May Griffith,Rosemarie Osborne,Rejean Munger,Xiaojuan Xiong,Charles J. Doillon,Noelani L. C. Laycock,Malik Hakim,Ying Song,Mitchell A. Watsky +8 more
TL;DR: Morphological and functional equivalents to human corneas that can be produced in vitro have immediate applications in toxicity and drug efficacy testing, and form the basis for future development of implantable tissues.
Journal ArticleDOI
Biomechanics and wound healing in the cornea
TL;DR: The cornea is described as a complex structural composite material with pronounced anisotropy and heterogeneity, current understanding of major biomechanical and reparative pathways that contribute to the corneal response to laser vision correction are summarized, and the role of these processes in ectasia, intraocular pressure measurement artifact, diffuse lamellar keratitis (DLK) andCorneal haze is reviewed.
Journal ArticleDOI
PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering.
Mehrdad Rafat,Fengfu Li,Per Fagerholm,Neil Lagali,Mitchell A. Watsky,Rejean Munger,Takeshi Matsuura,May Griffith +7 more
TL;DR: Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart and had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.
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Assessment of Corneal Biomechanical Properties and Their Variation with Age
TL;DR: The cornea demonstrates considerable stiffening with age with the behavior closely fitting an exponential power function typical of collagenous tissue.
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Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions.
Xiaodong Duan,Heather Sheardown +1 more