Journal ArticleDOI
Preparation and Rearrangement of N-Vinyl Nitrones: Synthesis of Spiroisoxazolines and Fluorene-Tethered Isoxazoles
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TLDR
N-Vinyl nitrones derived from fluorenone have been prepared via a copper-mediated coupling between fluore None oxime and vinyl boronic acids and undergo subsequent rearrangement and addition reactions that are distinct from the traditional [3 + 2] cycloaddition reactivity of nitrones.About:
This article is published in Organic Letters.The article was published on 2012-10-09. It has received 64 citations till now. The article focuses on the topics: Fluorenone & Fluorene.read more
Citations
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Recent Developments in the Synthesis and Reactivity of Isoxazoles: Metal Catalysis and Beyond
Feng Hu,Michal Szostak +1 more
TL;DR: Isoxazoles are important five-membered aromatic heterocycles in organic chemistry and many exciting advances in the synthesis and functionalization of isoxazoles have been reported as mentioned in this paper.
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Synthesis and Transformations of Nitrones for Organic Synthesis
TL;DR: The nitrones obtained are key intermediates for the synthesis of biologically important nitrogen compounds and will provide the strategies and means for the construction of nitrogen compounds.
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Metal-Involving Synthesis and Reactions of Oximes
TL;DR: This consideration gives a general outlook of reaction routes, mechanisms, and driving forces and underlines the potential of metal-involving conversions of oxime species for application in various fields of chemistry and draws attention to the emerging putative targets.
Journal ArticleDOI
Diverse Applications of Nitrones for the Synthesis of Heterocyclic Compounds
TL;DR: The use of [3+2]-dipolar cycloaddition reactions of nitrones for the synthesis of heterocyclic compounds has been extensively studied in the literature as mentioned in this paper.
References
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Journal ArticleDOI
Polyfluorenes: Twenty years of progress
TL;DR: In the last three years this research field has literally exploded because of polyfluorenes' exceptional electrooptical properties for applications in light-emitting diodes.
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Asymmetric 1,3-dipolar cycloadditions
TL;DR: In this article, a review of asymmetric 1,3-dipolar cycloaddition reactions involving a variety of heteroylides (or ylide equivalents) and dipolarophiles is presented.
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Copper-Promoted Carbon-HeteroatomBond Cross-Coupling with Boronic Acids and Derivatives
TL;DR: The Narylation/O-arylation methodology is now a powerful new synthetic tool, made even more attractive by the mild conditions required as discussed by the authors, and significant progress has been made in expanding the scope and the applications as well as understanding the mechanism of this reaction.
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An efficient diamine.copper complex-catalyzed coupling of arylboronic acids with imidazoles
James P. Collman,Min Zhong +1 more
TL;DR: A novel diamine-catalyzed intermolecular coupling of arylboronic acids with imidazoles in dichloromethane at room temperature to give a variety of N-arylimidazole in good to excellent yields is described.
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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
Mack Kuo,Hector R. Morbidoni,David Alland,Scott F. Sneddon,Brian B. Gourlie,Mark M. Staveski,Marina Leonard,Jill S. Gregory,Andrew Janjigian,Christopher Yee,James M. Musser,Barry N. Kreiswirth,Hiroyuki Iwamoto,Remo Perozzo,William R. Jacobs,James C. Sacchettini,David A. Fidock +16 more
TL;DR: These compounds do not require activation and are effective against wild-type and drug-resistant strains of M. tuberculosis and P. falciparum, and provide broader chemical diversity and elucidate key elements of inhibitor binding to InhA for subsequent chemical optimization.