Journal ArticleDOI
Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin.
Lei Li,Guohua Jiang,Guohua Jiang,Weijiang Yu,Depeng Liu,Hua Chen,Yongkun Liu,Zaizai Tong,Xiangdong Kong,Juming Yao +9 more
TLDR
It is suggested that L-valine modified chitosan-based multifunctional nanocarriers may be a promising drug delivery carrier for oral administration of insulin.About:
This article is published in Materials Science and Engineering: C.The article was published on 2017-01-01. It has received 107 citations till now. The article focuses on the topics: Nanocarriers & Drug delivery.read more
Citations
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Journal ArticleDOI
Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin
TL;DR: Results suggests the as-prepared microneedle patches developed in this study have a promising application in diabetes treatment via transdermal delivery.
Journal ArticleDOI
Rational Design of Nanocarriers for Intracellular Protein Delivery.
Xiaofei Qin,Changmin Yu,Jing Wei,Lin Li,Chengwu Zhang,Qiong Wu,Jinhua Liu,Shao Q. Yao,Wei Huang,Wei Huang +9 more
TL;DR: In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized and the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented.
Journal ArticleDOI
Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats
Zaizai Tong,Junyi Zhou,Jiaxing Zhong,Qiuju Tang,Zhentao Lei,Haipeng Luo,Pianpian Ma,Xiangdong Liu +7 more
TL;DR: The transdermal delivery of insulin to the diabetic rats ((insulin + GO x)-loaded MNs) presents an effective hypoglycemic effect compared to that of subcutaneous injection or only insulin- loaded MNs, which indicates the as-prepared MNs insulin delivery system could be of great importance for the applications in the therapy of diabetes.
Journal ArticleDOI
Oral Delivery of Biologics for Precision Medicine.
TL;DR: An overview of the current situation and future prospects in the field of oral delivery of biologics is provided and strategies for the specific targeting of gastrointestinal regions—stomach, small bowel, and colon—cell populations, and internalization pathways, are analyzed.
Journal ArticleDOI
Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats.
TL;DR: This work suggests that as-prepared Ca2+/Alg-Mal microneedles can be used to encapsulate insulin and have a potential application in diabetes treatment via transdermal ingestion.
References
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Journal ArticleDOI
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
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Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
Meera George,T. Emilia Abraham +1 more
TL;DR: Alginate, being an anionic polymer with carboxyl end groups, is a good mucoadhesive agent and cross-linked alginate has more capacity to retain the entrapped drugs and mixing of alginates with other polymers such as neutral gums, chitosan, and eudragit have been found to solve the problem of drug leaching.
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Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
M. Lepore,S. Pampanelli,Carmine G. Fanelli,Francesca Porcellati,L Bartocci,A. Di Vincenzo,C Cordoni,E Costa,Paolo Brunetti,Geremia B. Bolli +9 more
TL;DR: Glargine is a peakless insulin, it lasts nearly 24 h, it has lower intersubject variability than NPH and ultralente, and it closely mimics CSII, the gold standard of basal insulin replacement.
Journal ArticleDOI
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
Nicolaas G. M. Schipper,Susanne Olsson,Janet Hoogstraate,Albertus G. deBoer,Kjell M. Vårum,Per Artursson +5 more
TL;DR: The binding and absorption enhancing effects of chitosans on epithelial cells are mediated through their positive charges, which results in a structural reorganisation of tight junction-associated proteins which is followed by enhanced transport through the paracellular pathway.