Journal ArticleDOI
Presynaptic nicotinic ACh receptors.
Reads0
Chats0
TLDR
Nicotinic ACh receptors in the CNS are composed of a diverse array of subunits and have a range of pharmacological properties but despite the fact that they are ligand-gated cation channels, their physiological functions have not been determined.About:
This article is published in Trends in Neurosciences.The article was published on 1997-02-01. It has received 1285 citations till now. The article focuses on the topics: Alpha-4 beta-2 nicotinic receptor & Nicotinic agonist.read more
Citations
More filters
Journal Article
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
TL;DR: The activation of SNS during an immune response might be aimed to localize the inflammatory response, through induction of neutrophil accumulation and stimulation of more specific humoral immune responses, although systemically it may suppress Th1 responses, and, thus protect the organism from the detrimental effects of proinflammatory cytokines and other products of activated macrophages.
Journal ArticleDOI
Mammalian nicotinic acetylcholine receptors: from structure to function.
TL;DR: This review provides a comprehensive overview of the advancement of functional and genetic studies in the late 1980s and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body.
Journal ArticleDOI
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
John A. Dani,Daniel Bertrand +1 more
TL;DR: Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics.
Journal ArticleDOI
Attention, Uncertainty, and Free-Energy
Harriet Feldman,Karl J. Friston +1 more
TL;DR: It is shown that if the precision depends on the states, one can explain many aspects of attention, including attentional bias or gating, competition for attentional resources, attentional capture and associated speed-accuracy trade-offs.
Journal ArticleDOI
Neuronal nicotinic receptors: from structure to pathology
Cecilia Gotti,Francesco Clementi +1 more
TL;DR: This review will attempt to survey the major achievements reached in the study of the structure and function of NAChRs by examining their regional and cellular localisation and the molecular basis of their functional diversity mainly in pharmacological and biochemical terms.
References
More filters
Journal ArticleDOI
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
TL;DR: The results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system.
Journal ArticleDOI
Protein tyrosine kinase PYK2 involved in Ca 2+ -induced regulation of ion channel and MAP kinase functions
Sima Lev,Herman Moreno,Ricardo Martinez,Peter Canoll,Elior Peles,JoséM. Musacchio,Gregory D. Plowman,Bernardo Rudy,Joseph Schlessinger +8 more
TL;DR: PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
Journal ArticleDOI
Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
Etsuko Wada,Keiji Wada,Jim Boulter,Evan S. Deneris,Steve Heinemann,Jim Patrick,Larry W. Swanson +6 more
TL;DR: Nine different [35S]‐complementary ribonucleic acid (cRNA) probes were used in the present study to map the distribution of these nAChR subunit mRNAs throughout the central nervous system (CNS) of the rat.
Journal ArticleDOI
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
TL;DR: Findings reveal that CNS nAChRs enhance fast excitatory transmission, providing a likely mechanism for the complex behavioral effects of nicotine.
Related Papers (5)
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Lorna W. Role,Darwin K. Berg +1 more