Journal ArticleDOI
Prevalence of repetitive and reward-seeking behaviors in Parkinson disease
Valerie Voon,K. Hassan,Mateusz Zurowski,M. de Souza,Teri Thomsen,Susan H. Fox,Anthony E. Lang,Janis M. Miyasaki +7 more
TLDR
This study surveyed 297 patients with Parkinson disease with systematic screens and rigorous definitional criteria and found pathologic hypersexuality lifetime prevalence was 2.4%, which increases to 13.7% in patients on dopamine agonists.Abstract:
We surveyed 297 patients with Parkinson disease (PD) with systematic screens and rigorous definitional criteria. Pathologic hypersexuality lifetime prevalence was 2.4%. Compulsive shopping was 0.7%. Combined with our pathologic gambling data, the lifetime prevalence of these behaviors was 6.1% and increases to 13.7% in patients on dopamine agonists.read more
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Impulse Control Disorders in Parkinson Disease: A Cross-Sectional Study of 3090 Patients
Daniel Weintraub,Juergen Koester,Marc N. Potenza,Andrew Siderowf,Mark Stacy,Valerie Voon,Jacqueline Whetteckey,Glen Wunderlich,Anthony E. Lang +8 more
TL;DR: Dopamine agonist treatment in PD is associated with 2- to 3.5-fold increased odds of having an ICD, which represents a drug class relationship across ICDs.
Journal ArticleDOI
Introduction to Behavioral Addictions
TL;DR: Growing evidence suggests that behavioral addictions resemble substance addictions in many domains, including natural history, phenomenology, tolerance, comorbidity, overlapping genetic contribution, neurobiological mechanisms, and response to treatment, supporting the DSM-V Task Force proposed new category of Addiction and Related Disorders encompassing both substance use disorders and non-substance addictions.
Journal ArticleDOI
Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Thomas Steeves,Thomas Steeves,Janis M. Miyasaki,Mateusz Zurowski,Ae Lang,Giovanna Pellecchia,T. van Eimeren,Pablo Rusjan,Sylvain Houle,Antonio P. Strafella,Antonio P. Strafella,Antonio P. Strafella +11 more
TL;DR: This study describes results of a PET study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists and presents the first evidence of these phenomena in pathological gambling.
Journal ArticleDOI
The neurobiology of pathological gambling and drug addiction: an overview and new findings
TL;DR: Data suggest a closer relationship betweenPG and substance use disorders than exists between PG and obsessive-compulsive disorder and implications for prevention and treatment strategies will be discussed.
Journal ArticleDOI
Validation of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease
Daniel Weintraub,Staci Hoops,Judy A. Shea,Judy A. Shea,Kelly E. Lyons,Rajesh Pahwa,Erika Driver-Dunckley,Charles H. Adler,Marc N. Potenza,Janis M. Miyasaki,Andrew Siderowf,John E. Duda,John E. Duda,Howard I. Hurtig,Amy Colcher,Stacy Horn,Matthew B. Stern,Matthew B. Stern,Valerie Voon +18 more
TL;DR: Scores on the QUIP appear to be valid as a self‐assessment screening instrument for a range of ICDs and other compulsive behaviors that occur in PD, and a shortened version may perform as well as the full version.
References
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Journal Article
Compulsive buying : a report of 20 cases
TL;DR: Compulsive buying may cause significant psychological, interpersonal, and financial difficulties; may co-occur with other psychiatric disorders; may be treatable; and should be further studied as a mental disorder in its own right.
Journal ArticleDOI
Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies
TL;DR: Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction that develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously administered DRT.
Journal ArticleDOI
Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome.
Andrew Evans,Regina Katzenschlager,Dominic C. Paviour,John D. O'Sullivan,Silke Appel,Andrew D. Lawrence,Andrew J. Lees +6 more
TL;DR: Punding was associated with very high doses of dopamine replacement therapy often related to a pattern of chronic inappropriate overuse of dopaminergic medication in patients with Parkinson's disease as discussed by the authors.
Journal ArticleDOI
Prospective prevalence of pathologic gambling and medication association in Parkinson disease.
Valerie Voon,K. Hassan,Mateusz Zurowski,Sarah Duff-Canning,M. de Souza,Susan H. Fox,Anthony E. Lang,Janis M. Miyasaki +7 more
TL;DR: PG was associated with earlier PD onset and with dopamine agonists but not with agonist subtype or doses, and no association with a potent D3 receptor agonist was found.
Journal ArticleDOI
Pathologic gambling in Parkinson's disease: a behavioral manifestation of pharmacologic treatment?
José Antonio Molina,María José Sáinz‐Artiga,Alicia Fraile,Félix Javier Jiménez-Jiménez,Clara Villanueva,M. Ortí-Pareja,Félix Bermejo‐P +6 more
TL;DR: The gambling behavior appears more often in the “on” periods of motor fluctuations and it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson’s disease and motor fluctuations.