Profiling of molecular interactions in real time using acoustic detection.
Benjamin Godber,Mark John Frogley,Marian Rehak,Alexander Sleptsov,Kevin S.J. Thompson,Yildiz Uludag,Mark E. Cooper +6 more
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TLDR
This work has developed a novel acoustic detection technology, which they term resonant acoustic profiling (RAP), which builds on the fundamental basics of the "quartz crystal microbalance" or "QCM" with several key additional features including two- or four-channel automated sample delivery, in-line referencing and microfluidic sensor 'cassettes' that are pre-coated with easy-to-use surface chemistries.About:
This article is published in Biosensors and Bioelectronics.The article was published on 2007-04-15 and is currently open access. It has received 15 citations till now. The article focuses on the topics: Quartz crystal microbalance.read more
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Phononic crystals for liquid sensor applications
Ralf Lucklum,Jing Li,Jing Li +2 more
TL;DR: In this article, the properties of 1D phononic crystals were analyzed in terms of the effective acoustic impedance and the resulting transmission behavior and experimentally verified with the layer multiple-scattering theory.
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Microfluidic chips for immunoassays.
TL;DR: This review focuses on the description of recent achievements in microfluidic chips for immunoassays categorized by their detection method and highlights interesting strategies for sensitive immunosensing configurations, multiplexed analysis, and POC diagnostics in micro fluidic immunosensors.
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Two-dimensional phononic crystal sensor based on a cavity mode
TL;DR: In this article, a two-dimensional phononic crystal with in-plane wave incidence was used for acoustic liquid sensors, which is made up of a steel plate having two regular arrays of holes and a cavity in between.
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Optimizing immobilization on two-dimensional carboxyl surface: pH dependence of antibody orientation and antigen binding capacity.
TL;DR: It is shown that successful immobilization is highly dependent on surface pK(a), antibody pI, and pH of immobilization buffer, and the orientation of the antibodies on the surface had a profound effect on the antigen binding capacity of the immobilized antibodies.
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Systematic investigation of biomolecular interactions using combined frequency and motional resistance measurements
Henrik Anderson,Gunilla Wingqvist,Gunilla Wingqvist,Thomas Weissbach,Daniel Wallinder,Ilia Katardjiev,Björn Ingemarsson +6 more
TL;DR: In this paper, the resonance frequency of acoustic biosensors is used as a label-free technique for detecting mass changes on sensor surfaces, in combination with an appropriate continuous flow system.
References
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Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung
TL;DR: In this paper, eigenfrequenz der Platte infolge Vergroserung der schwingenden Masse is vermessen, so das eine empirische Eichung bei der Schichtwagung mit Schwingquarzen entfallt.
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Use of quartz vibration for weighing thin films on a microbalance
G. Sauerbrey,F. Sauerbrey +1 more
Journal Article
The use of quarts oscillators for weighing thin layers and for microweighing
G. Sauerbrey,G.Z. Sauerbrey +1 more
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Simultaneous frequency and dissipation factor QCM measurements of biomolecular adsorption and cell adhesion
Michael Rodahl,Fredrik Höök,Claes Fredriksson,Craig A. Keller,Anatol Krozer,Peter Brzezinski,M. V. Voinova,Bengt Herbert Kasemo +7 more
TL;DR: It is shown theoretically that viscoelastic layers with thicknesses comparable to the biofilms studied in this work can induce energy dissipation of the same magnitude as the measured ones.
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Piezoelectric Mass‐Sensing Devices as Biosensors—An Alternative to Optical Biosensors?
TL;DR: The future will show whether the quartz-crystal microbalance will assert itself against established label-free sensor devices such as surface plasmon resonance spectroscopy and interferometry.