Journal ArticleDOI
Progress with stem cell therapies for tendon tissue regeneration.
Reads0
Chats0
TLDR
The role of a variety of regenerative medicine options to induce and favor regeneration and healing of tendon tissue, focusing on the role of mesenchymal stem cell therapy and their derivatives is discussed.Abstract:
Chronic musculoskeletal pain is very prevalent, and accounts for major health-care expenses Many of the present therapeutic modalities are only partially effective, and great interest is now posedread more
Citations
More filters
Journal ArticleDOI
Small interfering RNAs in tendon homeostasis.
Giuseppe Gargano,Giuseppe Gargano,Antonio Oliviero,Antonio Oliviero,Francesco Oliva,Francesco Oliva,Nicola Maffulli +6 more
TL;DR: In this paper, small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing and are useful to study reparative processes of tendons and identify possible therapeutic targets in tendon healing.
Journal ArticleDOI
The Biomechanics of Cartilage-An Overview.
J. Eschweiler,Nils Horn,Bjoern Rath,Marcel Betsch,Alice Baroncini,Markus Tingart,Filippo Migliorini +6 more
TL;DR: In this article, an overview is given about different testing (load tests) methods as well as different modeling approaches, and a short introduction to a more complex model is given, which is required to understand how interstitial water contributes toward the viscoelastic behavior of AC.
Journal ArticleDOI
Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells.
Maria Camilla Ciardulli,Luigi Marino,Erwin Pavel Lamparelli,Maurizio Guida,Nicholas R. Forsyth,Carmine Selleri,Giovanna Della Porta,Nicola Maffulli,Nicola Maffulli +8 more
TL;DR: In the same conditions, both cell types showed specific alignment and shape modification with a length/width ratio increase, suggesting their response in activating tenogenic commitment events, and they both potential use in 3D in vitro tissue-engineering protocols.
Journal ArticleDOI
Tendon-bioinspired wavy nanofibrous scaffolds provide tunable anisotropy and promote tenogenesis for tendon tissue engineering.
TL;DR: In this article, a tendon-biomimetic nanofibrous scaffolds with mesenchymal stem cells was developed to improve the unsatisfactory outcomes of traditional treatments in tendon repair.
Journal ArticleDOI
Co-Electrospun Silk Fibroin and Gelatin Methacryloyl Sheet Seeded with Mesenchymal Stem Cells for Tendon Regeneration.
Yumeng Xue,Han-Jun Kim,Junmin Lee,Yaowen Liu,Tyler Hoffman,Yi Chen,Xingwu Zhou,Wujin Sun,Shiming Zhang,Hyun-Jong Cho,Jiyong Lee,Heemin Kang,WonHyoung Ryu,Chang-Moon Lee,Samad Ahadian,Mehmet R. Dokmeci,Bo Li,KangJu Lee,Ali Khademhosseini +18 more
TL;DR: Histological analysis and tenogenesis-related immunofluorescence staining indicate SG7 scaffolds demonstrate enhanced in vivo tendon tissue regeneration compared to other groups, suggesting rational combinations of SF and GelMA hybrid nanofibers may help to improve therapeutic outcomes and address the challenges of tissue-engineered scaffolds for tendon regeneration.
References
More filters
Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
Yanming Bi,Driss Ehirchiou,Tina M. Kilts,Colette A. Inkson,Mildred C. Embree,Wataru Sonoyama,Li Li,Arabella I. Leet,Byoung Moo Seo,Li Zhang,Songtao Shi,Songtao Shi,Marian F. Young +12 more
TL;DR: It is shown that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity and could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo.
Journal ArticleDOI
Physiology and Healing Dynamics of Chronic Cutaneous Wounds
TL;DR: A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.
Journal ArticleDOI
Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options.
TL;DR: Screening the genes expressed during tendon morphogenesis and determining the growth factors most crucial for tendon development will likely lead to treatment options that result in superior repair tissue and ultimately improved functional outcomes.
Related Papers (5)
Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges
Asiyeh Shojaee,Abbas Parham +1 more