Journal ArticleDOI
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Paolo Gionchetti,Fernando Rizzello,Ulf Helwig,A. Venturi,Karen M. Lammers,Patrizia Brigidi,Beatrice Vitali,Gilberto Poggioli,Mario Miglioli,Massimo Campieri +9 more
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TLDR
Treatment with VSL#3 is effective in the prevention of the onset of acute pouchitis and improves quality of life of patients with ileal pouch-anal anastomosis.About:
This article is published in Gastroenterology.The article was published on 2000-04-01. It has received 1042 citations till now. The article focuses on the topics: Pouchitis & Placebo-controlled study.read more
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Unravelling the pathogenesis of inflammatory bowel disease
TL;DR: Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation as mentioned in this paper, which have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis.
Journal ArticleDOI
Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee.
Asher Kornbluth,David B. Sachar +1 more
TL;DR: Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifically valid research, and are applicable to all physicians who address the subject regardless of specialty training or interests.
Journal ArticleDOI
The gut microbiota and host health: a new clinical frontier
Julian R. Marchesi,David H. Adams,Francesca Fava,Gerben D. A. Hermes,Gideon M. Hirschfield,Georgina L. Hold,Mohammed Nabil Quraishi,James Kinross,Hauke Smidt,Kieran Tuohy,Linda V. Thomas,Erwin G. Zoetendal,Ailsa Hart +12 more
TL;DR: The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
Journal ArticleDOI
Guidelines for the management of inflammatory bowel disease in adults
Craig Mowat,Andrew Cole,Al Windsor,Tariq Ahmad,Ian D. Arnott,R Driscoll,Sally G. Mitton,Timothy R. Orchard,Matthew D. Rutter,Lisa Younge,Charlie W. Lees,Gwo-Tzer Ho,Jack Satsangi,Stuart Bloom +13 more
TL;DR: The present document is intended primarily for the use of clinicians in the United Kingdom, and serves to replace the previous BSG guidelines in IBD, while complementing recent consensus statements published by the European Crohn's and Colitis Organisation (ECCO).
Journal ArticleDOI
Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
References
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Journal ArticleDOI
Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
Paolo Gionchetti,Fernando Rizzello,A. Venturi,Patrizia Brigidi,Diego Matteuzzi,Gabriele Bazzocchi,Gilberto Poggioli,Mario Miglioli,Massimo Campieri +8 more
TL;DR: Oral administration of a probiotic preparation containing 5 x 10 per gram of viable lyophilized bacteria of 4 strains of lactobacilli, 3 strains of bifidobacteria, and 1 strain of Streptococcus salivarius subsp.
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A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease
Gordon H. Guyatt,Alba Mitchell,E. Jan Irvine,Joel Singer,Nancy Williams,R.L. Goodacre,Cathy Tompkins +6 more
TL;DR: The Inflammatory Bowel Disease Questionnaire shows promise as a measure of health status for clinical trials in IBD, and responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease.
Journal ArticleDOI
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial.
TL;DR: The results suggest that treatment with a non-pathogenic E. coli has an equivalent effect to mesalazine in maintaining remission of ulcerative colitis.
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Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Karen L. Madsen,Anthony Cornish,Paul R. Soper,Conor McKaigney,Humberto Jijon,Christine Yachimec,Jason Doyle,Lawrence D. Jewell,Claudio De Simone +8 more
TL;DR: In vitro studies showed that epithelial barrier function and resistance to Salmonella invasion could be enhanced by exposure to a proteinaceous soluble factor secreted by the bacteria found in the VSL#3 compound.
Journal ArticleDOI
Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis.
TL;DR: A trial was conducted to test the effects of probiotic treatment with an oral preparation of non‐pathogenic E. coli in the hypothesis that the intestinal environment may contribute to the pathophysiology of ulcerative colitis.