Journal ArticleDOI
Protective role of withaferin-A on 7,12-dimethylbenz(a)anthracene-induced genotoxicity in bone marrow of Syrian golden hamsters.
Kuppusamy Panjamurthy,Shanmugam Manoharan,Venugopal P. Menon,Madhavan R. Nirmal,Namasivayam Senthil +4 more
TLDR
Hamsters pretreated with withaferin‐A intraperitonealy 2 h before the injection of DMBA, significantly reduced the frequency of MnPCEs and chromosomal aberrations such as chromosomal break, gap, minute, and fragment.Abstract:
The present study has investigated the antigenotoxic effect of withaferin-A, a steroidal lactone obtained from the roots and leaves of Withania somnifera, in 7,12-dimethylbenz(a)anthracene (DMBA)-induced genotoxicity. Measurement of the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and chromosomal aberrations is used as cytogenetic endpoints. A single intraperitoneal injection of DMBA (30 mg/kg b.w.) to golden Syrian hamsters resulted in marked elevation in the frequency of MnPCEs and aberrations in the chromosomal structure. Hamsters pretreated with withaferin-A intraperitonealy 2 h before the injection of DMBA, significantly reduced the frequency of MnPCEs and chromosomal aberrations such as chromosomal break, gap, minute, and fragment. Our results thus demonstrated the antigenotoxic effect of withaferin-A in DMBA-induced genotoxicity in the bone marrow of golden Syrian hamsters.read more
Citations
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Journal ArticleDOI
Molecular insight in the multifunctional activities of Withaferin A
TL;DR: This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A.
Journal ArticleDOI
Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action
In-Chul Lee,Bu Young Choi +1 more
TL;DR: This review highlights the mechanistic aspects underlying anticancer effects of withaferin-A, which suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, pro-proliferative and apoptosis-inducing properties.
Journal ArticleDOI
Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats.
TL;DR: Oral administration of ferulic acid at a dose of 40 mg/kg body weight to rats treated with DMBA significantly prevented the tumor formation in 80% of animals and significantly protected the biochemical and molecular abnormalities in DMBA treated rats.
Book ChapterDOI
Withanolides and Related Steroids
Rosana I. Misico,Viviana E. Nicotra,Juan C. Oberti,Gloria Estela Barboza,Roberto R. Gil,Gerardo Burton +5 more
TL;DR: Withania is the parent genus of the withanolides and a special section is devoted to the new structures isolated from species in this genus, and all other new structures are grouped by structural types.
Journal ArticleDOI
Pleiotrophic effects of natural products in ROS-induced carcinogenesis: the role of plant-derived natural products in oral cancer chemoprevention.
Dominique Ziech,Ioannis Anestopoulos,Rania Hanafi,Georgia Persephoni Voulgaridou,Rodrigo Franco,Alexandros G. Georgakilas,Aglaia Pappa,Mihalis I. Panayiotidis +7 more
TL;DR: The evidence as to how some of these natural products exert their chemopreventive effects in human carcinogenesis are reviewed, placing particular emphasis on oral cancer where significant efforts have been made in alternative therapeutic strategies such as the use of plant-derived natural products.
References
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Journal Article
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