Journal ArticleDOI
Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium.
Hing Man Chan,M. George Cherian +1 more
TLDR
Both intracellular GSH and MT levels may provide protection against cytotoxicity of Cd in liver and even at low GSH levels, MT could partially protect the hepatic cells from Cd cytot toxicity.About:
This article is published in Toxicology.The article was published on 1992-01-01. It has received 115 citations till now. The article focuses on the topics: Buthionine sulfoximine & Glutathione.read more
Citations
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Journal ArticleDOI
Oxidative Stress as a Mechanism of Chronic Cadmium-Induced Hepatotoxicity and Renal Toxicity and Protection by Antioxidants☆☆☆★
TL;DR: In this article, the role of oxidative stress in chronic cadmium toxicity and its prevention by cotreatment with antioxidants was investigated, and a Japanese hepatoprotective drug, Stronger Neo-Minophagen C, containing glycyrrhizin, glycine, and cysteine, was also effective in reducing the chronic Cd nephrotoxicity.
Journal ArticleDOI
Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium.
TL;DR: These experiments showed that the formation of thiobarbituric acid reactive substance (TBARS) did not strictly depend on how well the antioxidant enzyme worked, and it appeared that TBARS removal by vitamin E did not restore the three enzyme activities at all.
Journal ArticleDOI
Interactions between cadmium and zinc in the organism.
TL;DR: In this paper, the interactions between zinc and cadmium in humans and animals are discussed on the basis of the available literature and their own results, against the background of general population exposure to Cd and common nutritional deficiency of Zn.
Scientific Opinion of the Panel on Contaminants in the Food Chain
Jan Alexander,Diane Benford,Andrew Cockburn,Jean-Pierre Cravedi,Eugenia Dogliotti,Alessandro Di Domenico,María Luisa Fernández-Cruz,Peter Fürst,Johanna Fink-Gremmels,Lodovico Galli,Philippe Grandjean,Jadwiga Gzyl,Gerhard Heinemeyer,Antonio Mutti,Josef Rudolf Schlatter,Rolaf van Leeuwen,Carlos Van Peteghem,Philippe Verger +17 more
TL;DR: The Scientific Panel on Contaminants in the Food Chain (CONTAM Panel) concluded that because PTX-group toxins do not share the same mechanism of action as OAgroup toxins they should not be included in the regulatory limit for OA- group toxins.
Journal ArticleDOI
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
Cagatay Günes,Rainer Heuchel,Oleg Georgiev,Karl Heinz Müller,Peter Lichtlen,Horst Blüthmann,Silvia Marino,Adriano Aguzzi,Walter Schaffner +8 more
TL;DR: It is shown that primary mouse embryo fibroblasts lacking MTF‐1 show increased susceptibility to the cytotoxic effects of cadmium or hydrogen peroxide, and may help to control metal homeostasis and probably cellular redox state, especially during liver development.
References
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Journal ArticleDOI
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
O.W. Griffith,A. Meister +1 more
TL;DR: The findings support the conclusion that the S-alkyl moiety of the sulfoximine binds at the enzyme site that normally binds the acceptor amino acid and increases in a manner which is parallel to those of the corresponding isosteric accepter amino acid substrates, i.e. glycine, alanine, and alpha-aminobutyrate.
Journal ArticleDOI
Biochemical Effects of Mercury, Cadmium, and Lead
B L Vallee,D D Ulmer +1 more
TL;DR: A review of the chemical and biochemical effects of mercury, acadmium and lead is presented and the means available to identify their biochemical sites of action are discussed.
Journal ArticleDOI
Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization.
and A Meister,S S Tate +1 more
Journal Article
Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review
Bradley A. Arrick,Carl Nathan +1 more
TL;DR: It seems likely that alterations in glutathione metabolism of tumor or host as a result of one therapeutic intervention may affect the outcome of concurrent treatments, and knowledge of these interactions may be useful in designing combination therapy for neoplastic disease.