Protein-protein interaction network analysis of cirrhosis liver disease
Akram Safaei,Mostafa Rezaei Tavirani,Afsaneh Arefi Oskouei,Mona Zamanian Azodi,Seyed Reza Mohebbi,Abdolrahim Nikzamir +5 more
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TLDR
The result indicates that regulation of lipid metabolism and cell survival are important biological processes involved in cirrhosis disease.Abstract:
Aim: Evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research. Background: In clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. Evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. Since the early detection of cirrhosis is a clinical problem, achieving a sensitive, specific and predictive novel method based on biomarkers is an important task. Methods: Essential analysis, such as gene ontology (GO) enrichment and protein-protein interactions (PPI) was undergone EXPASy, STRING Database and DAVID Bioinformatics Resources query. Results: Based on GO analysis, most of proteins are located in the endoplasmic reticulum lumen, intracellular organelle lumen, membrane-enclosed lumen, and extracellular region. The relevant molecular functions are actin binding, metal ion binding, cation binding and ion binding. Cell adhesion, biological adhesion, cellular amino acid derivative, metabolic process and homeostatic process are the related processes. Protein-protein interaction network analysis introduced five proteins (fibroblast growth factor receptor 4, tropomyosin 4, tropomyosin 2 (beta), lectin, Lectin galactoside-binding soluble 3 binding protein and apolipoprotein A-I) as hub and bottleneck proteins. Conclusion: Our result indicates that regulation of lipid metabolism and cell survival are important biological processes involved in cirrhosis disease. More investigation of above mentioned proteins will provide a better understanding of cirrhosis disease.read more
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Introduction of inflammatory bowel disease biomarkers panel using protein-protein interaction (PPI) network analysis.
Hamid Asadzadeh-Aghdaee,Shabnam Shahrokh,Mohsen Norouzinia,Mostafa Hosseini,Aliasghar Keramatinia,Mostafa Jamalan,Bijan Naghibzadeh,Ali Sadeghi,Somayeh Jahani Sherafat,Mohammad Reza Zali +9 more
TL;DR: A protein-protein interaction network construction for IBD indicates that there are seven hub-bottleneck proteins in the IBD network, and the essential roles of these key proteins are revealed in the integrity of the network.
Journal ArticleDOI
Introducing crucial protein panel of gastric adenocarcinoma disease
Mostafa Rezaei-Tavirani,Majid Rezaei-Tavirani,Vahid Mansouri,Seyed Mohammad Mahdavi,Reza Valizadeh,Mohammad Rostami-Nejad,Mohammad Reza Zali +6 more
TL;DR: This PPI network analysis is used to introduce the involved crucial proteins in Gastric adenocarcinoma and may be a useful probe in the management of GA.
Journal ArticleDOI
Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach.
Hassan Peyvandi,Ali Asghar Peyvandi,Akram Safaei,Mona Zamanian Azodi,Mostafa Rezaei-Tavirani +4 more
TL;DR: 12 crucial proteins are determined that 4 of them can be introduce as a possible biomarker panel including YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer.
Journal ArticleDOI
Proteome profiling of low grade serous ovarian cancer.
Haniyeh Bashizadeh Fakhar,Hakimeh Zali,Mostafa Rezaie-Tavirani,Roya Faraji Darkhaneh,Babak Babaabasi +4 more
TL;DR: It can be concluded that regulation of gene expression can have a critical role in the pathology of Low-grade serous ovarian cancer.
Journal ArticleDOI
Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy.
Mohammad Rostami-Nejad,Mostafa Rezaei-Tavirani,Mohammad-Mehdi Zadeh-Esmaeel,Sina Rezaei-Tavirani,Zahra Akbari,Somayeh Esmaeili,Farshad Okhovatian +6 more
TL;DR: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.
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