Journal ArticleDOI
Protein release from gelatin matrices
Yoshito Ikada,Yasuhiko Tabata +1 more
TLDR
Experimental data show that sustained release of growth factor from the gelatin hydrogels is very effective in exerting the biological functions of the growth factor.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-05-04. It has received 787 citations till now. The article focuses on the topics: Gelatin & Self-healing hydrogels.read more
Citations
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Electrospinning: a fascinating fiber fabrication technique.
Nandana Bhardwaj,Subhas C. Kundu +1 more
TL;DR: This review presents an overview of the electrospinning technique with its promising advantages and potential applications, and focuses on varied applications of electrospun fibers in different fields.
Journal ArticleDOI
Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications
TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.
Journal ArticleDOI
Gelatin as a delivery vehicle for the controlled release of bioactive molecules.
TL;DR: This review will emphasize how biomolecules released from gelatin controlled-release systems are able to retain their biological activity, allowing for their use in tissue engineering, therapeutic angiogenesis, gene therapy, and drug delivery applications.
Journal ArticleDOI
Hydrogels for protein delivery.
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A review of the recent developments in biocomposites based on natural fibres and their application perspectives
TL;DR: In this paper, a brief outline of work that covers in the area of biocomposites, major class of biodegradable polymers, natural fibres, as well as their manufacturing techniques and properties has been highlighted.
References
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Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Journal ArticleDOI
Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres
TL;DR: Stability studies showed that the encapsulation of an enzyme inside PLGA microspheres can protect them from activity loss, and in vitro release studies revealed that different release profiles and release rates can be achieved by simply modifying factors in the preparation procedure.
Journal ArticleDOI
Growth factors in the extracellular matrix.
Jussi Taipale,Jorma Keski-Oja +1 more
TL;DR: The ability of extracellular proteins to pro‐cess complex information in the absence of new protein synthesis is illustrated in blood clotting and complement pathways, suggesting thatextracellular matrix plays a major role in the control of growth factor signaling.
Journal ArticleDOI
A dual receptor system is required for basic fibroblast growth factor activity
Michael Klagsbrun,Andrew Baird +1 more
TL;DR: The existence of at least seven genes encoding FGF family members, at least four genes encoding high affinity recep- tors, and heterogeneous populations of HSPG low affinity receptors on cell surfaces and in the extracellular matrix suggests novel mechanisms for regulating FGF activity and determining responsiveness of target cells to FGF.
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Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities.
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