Journal ArticleDOI
Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging
Lucilla Parnetti,Roberto Tarducci,O. Presciutti,David T. Lowenthal,Margherita Pippi,Barbara Palumbo,G. Gobbi,Gian Piero Pelliccioli,Umberto Senin +8 more
TLDR
It can be concluded that in vivo 1H-MRS can contribute to the knowledge of pathophysiology of AD, giving neurochemical details of both gray and white matter, and the gray matter NAA/ml ratio seems to be able to differentiate normal cerebral aging from Alzheimer's disease.About:
This article is published in Mechanisms of Ageing and Development.The article was published on 1997-07-01. It has received 123 citations till now. The article focuses on the topics: White matter & Grey matter.read more
Citations
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Journal ArticleDOI
Neuroimaging and early diagnosis of Alzheimer disease : a look to the future
TL;DR: In this paper, the authors used both volumetric and subtraction MR techniques to quantify and monitor dementia progression and rates of regional atrophy in the hippocampus and entorhinal cortex.
Journal ArticleDOI
Magnetic resonance spectroscopy in AD
TL;DR: MRS has promise for predicting cognitive status and monitoring pharmacologic efficacy, and can assess cortical and subcortical neurochemical change, but is yet to test prospective samples and should be extended to include at least two MRS regions of interest.
Journal ArticleDOI
In vivo mapping of brain myo-inositol.
TL;DR: It is demonstrated that MICEST detection is feasible in the human brain at ultra high fields (7 T) without exceeding the allowed limits on radiofrequency specific absorption rate and potentially opens the way to image MI in vivo and to monitor its alteration in many disease conditions.
Journal ArticleDOI
Magnetic resonance spectroscopy in cognitive research
Amy J. Ross,Perminder S. Sachdev +1 more
TL;DR: It is concluded that MRS has potential applications for the study of cognitive processes in health and disease and may be used clinically for differential diagnosis, the early detection of pathology and the examination of longitudinal change.
Journal Article
Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury.
Grant Sinson,Linda J. Bagley,Kim M. Cecil,Maria Torchia,Joseph C. McGowan,Robert E. Lenkinski,Tracy K. McIntosh,Robert I. Grossman +7 more
TL;DR: MTR and MR spectroscopy can quantify damage after TBI, and NAA levels may be a sensitive indicator of the neuronal damage that results in a worse clinical outcome.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
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The Global Deterioration Scale for assessment of primary degenerative dementia.
TL;DR: The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages and have used it successfully for more than 5 years and validated it against behavioral, neuroanatomic, and neurophysiologic measures in patients with primary degeneratives dementia.
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Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
TL;DR: Immunocytochemical staining has shown that N-acetyl-aspartate-like immunoreactivity is localized in neurons, which are widely distributed throughout the brain.