Journal ArticleDOI
Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris
Tilo Henseler,Enno Christophers +1 more
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TLDR
Nonpustular psoriasis shows two distinct forms, one of which is hereditary, with early onset, and the other is sporadic and occurs in older age, which shows a strong tendency to become generalized.Abstract:
In 2,147 patients suffering from psoriasis, evaluation of the age of onset revealed two peaks, one occurring at the age of 16 years (female) or 22 years (males) and a second peak at the age of 60 years (female) or 57 years (males). Human lymphocyte antigen (HLA) tissue typing in 112 randomly assigned patients showed that HLA-Cw6, known to be at disequilibrium in psoriasis, is present in 85.3% of patients with early onset. In contrast, 14.7% patients with late onset showed this marker. Parents (father or mother) were affected in approximately half of the patients with early onset and in none belonging to the group with late onset. Furthermore, psoriasis in patients with early onset follows an irregular course and shows a strong tendency to become generalized. On the basis of clearly defined criteria (e.g., age of onset, heritability, and clinical course of disease), nonpustular psoriasis shows two distinct forms, one of which is hereditary, with early onset, and the other is sporadic and occurs in older age.read more
Citations
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Journal ArticleDOI
Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence
TL;DR: The data indicated that the occurrence of psoriasis varied according to age and geographic region, being more frequent in countries more distant from the equator and trends in incidence over time.
Journal ArticleDOI
Risk of myocardial infarction in patients with psoriasis.
Joel M. Gelfand,Andrea L. Neimann,Daniel B. Shin,Xingmei Wang,David J. Margolis,Andrea B. Troxel +5 more
TL;DR: Psoriasis may confer an independent risk of MI when controlling for major cardiovascular risk factors, and was greatest in young patients with severe psoriasis, which had an increased adjusted relative risk (RR) for MI that varied by age.
Journal ArticleDOI
Pathogenesis and clinical features of psoriasis.
TL;DR: Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis.
Journal ArticleDOI
Prevalence of cardiovascular risk factors in patients with psoriasis
Andrea L. Neimann,Daniel B. Shin,Xingmei Wang,David J. Margolis,Andrea B. Troxel,Joel M. Gelfand +5 more
TL;DR: Cardiovascular risk factors that are key components of the metabolic syndrome are more strongly associated with severe psoriasis than with mild Psoriasis.
Journal ArticleDOI
Psoriasis--epidemiology and clinical spectrum.
TL;DR: The prevalence of psoriasis is a lack of specific data, with the majority of studies reporting estimates only, which contrasts with other T‐cell mediated autoimmune diseases where the number of those affected is rising.
References
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Journal ArticleDOI
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