Journal ArticleDOI
Pathogenesis and clinical features of psoriasis.
TLDR
Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis.About:
This article is published in The Lancet.The article was published on 2007-07-21. It has received 1596 citations till now. The article focuses on the topics: Psoriasis & Psoriatic arthritis.read more
Citations
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Journal ArticleDOI
Mechanisms of Disease: Psoriasis.
TL;DR: Anti-TNF strategies have three variants: a humanized chimeric anti–TNF- α monoclonal antibody, a fully human monocolonal anti-T NF- α antibody, and a human p75 TNF-receptor Fc fusion protein.
Journal ArticleDOI
Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence
TL;DR: The data indicated that the occurrence of psoriasis varied according to age and geographic region, being more frequent in countries more distant from the equator and trends in incidence over time.
Journal ArticleDOI
Secukinumab in plaque psoriasis--results of two phase 3 trials.
Richard G. Langley,Boni E. Elewski,Mark Lebwohl,Kristian Reich,Christopher E.M. Griffiths,Kim A. Papp,Lluís Puig,Hidemi Nakagawa,Lynda Spelman,Bárður Sigurgeirsson,Enrique Rivas,Tsen-Fang Tsai,Norman Wasel,Stephen K. Tyring,Thomas Salko,Isabelle Hampele,Marianne Notter,Alexander Karpov,Silvia Helou,Charis Papavassilis +19 more
TL;DR: Secukinumab was effective for psoriasis in two randomized trials, validating interleukin-17A as a therapeutic target and the rates of infection were higher with secuk inumab than with placebo in both studies and were similar to those with etanercept.
Journal ArticleDOI
Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis
Christopher E.M. Griffiths,Bruce Strober,Peter C.M. van de Kerkhof,Vincent T. Ho,Roseanne Fidelus-Gort,Newman Yeilding,Cynthia Guzzo,Yichuan Xia,B. Zhou,Shu Li,Lisa T. Dooley,Neil H. Goldstein,Alan Menter +12 more
TL;DR: The efficacy of ustekinumab at a dose of 45 or 90 mg was superior to that of high-dose etanercept over a 12-week period in patients with psoriasis.
Journal ArticleDOI
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more
TL;DR: Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis.
References
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Journal ArticleDOI
Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use
Andrew Yule Finlay,G. K. Khan +1 more
TL;DR: This study confirmed that a topic eczema, psoriasis and generalized pruritus have a greater impact on quality of life than acne, basal cell carcinomas and viral warts.
Journal ArticleDOI
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Colin N. A. Palmer,Alan D. Irvine,Ana Terron-Kwiatkowski,Yiwei Zhao,Haihui Liao,Simon P. Lee,David Goudie,Aileen Sandilands,Linda E. Campbell,Frances J.D. Smith,Grainne M. O'Regan,Rosemarie Watson,Jo E Cecil,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Philip Fleckman,Sue Lewis-Jones,Gehan Arseculeratne,Ann Sergeant,Colin S. Munro,Brahim El Houate,Ken McElreavey,Liselotte Brydensholt Halkjaer,Hans Bisgaard,Somnath Mukhopadhyay,Somnath Mukhopadhyay,W.H. Irwin McLean +28 more
TL;DR: It is shown that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis.
Journal ArticleDOI
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Jocelyn Holash,Maisonpierre Peter C,Debra L Compton,Patricia Boland,C. R. Alexander,David Zagzag,George D. Yancopoulos,Stanley J. Wiegand +7 more
TL;DR: Evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels and regresses, leading to a secondarily avascular tumor and massive tumor cell loss.
Book
Rook's Textbook of Dermatology
Arthur Rook,Burns, Tony, Frcp +1 more
TL;DR: Rook's textbook of dermatology , Rook's textbooks of dermatologist, کتابخانه مرکزی دانشگاه ایران.
Journal ArticleDOI
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Peck Y. Ong,Takaaki Ohtake,Corinne Brandt,Ian Strickland,Mark Boguniewicz,Tomas Ganz,Richard L. Gallo,Donald Y.M. Leung +7 more
TL;DR: A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus.