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Journal ArticleDOI

Pulmonary atelectasis: a pathogenic perioperative entity.

Michelle Duggan, +1 more
- 01 Apr 2005 - 
- Vol. 102, Iss: 4, pp 838-854
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TLDR
The authors discuss the effects and implications of atelectasis in the perioperative period and illustrate how preventive measures may impact outcome and the impact of atElectasis and its prevention in acute lung injury.
Abstract
Atelectasis occurs in the dependent parts of the lungs of most patients who are anesthetized. Development of atelectasis is associated with decreased lung compliance, impairment of oxygenation, increased pulmonary vascular resistance, and development of lung injury. The adverse effects of atelectasis persist into the postoperative period and can impact patient recovery. This review article focuses on the causes, nature, and diagnosis of atelectasis. The authors discuss the effects and implications of atelectasis in the perioperative period and illustrate how preventive measures may impact outcome. In addition, they examine the impact of atelectasis and its prevention in acute lung injury.

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Citations
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Respiratory Complications in the Pediatric Postanesthesia Care Unit

TL;DR: The physiologic and pathophysiologic background and causes for respiratory complications in the PACU are explained and suggestions given for an optimization of the anesthesia management in the perioperative period.
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A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro

TL;DR: A prototype fibre optic oxygen sensor, compatible with clinical use, can detect rapid PO2 changes in vitro and is presented, which shows that the fidelity with which oxygen sensors can detect these arterial PO2 oscillations depends on the sensors’ speed of response.
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Detection of tidal recruitment/overdistension in lung-healthy mechanically ventilated patients under general anesthesia.

TL;DR: The distension index %E2, derived from the VDSCM considering flow-dependencies, seems able to identify tidal recruitment/overdistension induced by VT and PEEP independent of flow waveform in healthy lung-anesthetized patients.
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Con: low tidal volumes are indicated during one-lung ventilation.

TL;DR: During one-lung ventilation, reduced tidal volumes are aimed at avoiding the alveolar over-distension or stretching of lung parenchyma by the volumes of normal two-l lung ventilation, which is most closely related to mean airway pressure.
References
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Journal ArticleDOI

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.

TL;DR: In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
Journal ArticleDOI

The acute respiratory distress syndrome

TL;DR: An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.
Journal ArticleDOI

Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

TL;DR: As compared with conventional ventilation, the protective strategy was associated with improved survival at 28 days, a higher rate of weaning from mechanical ventilation, and a lower rate of barotrauma in patients with the acute respiratory distress syndrome.
Journal ArticleDOI

Ventilator-induced lung injury: lessons from experimental studies.

TL;DR: This paper presents experimental evidence for Increased Vascular Transmural Pressure Evidence for Alterations in Alveolar–Capillary Permeability Contributions of the Static and Dynamic Lung Volume Components to Ventilator-induced Edema High-volume Lung Edema Low Lung Volume Injury.
Journal ArticleDOI

Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.

TL;DR: Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and recruitment/derecruitment of the lung, and these physiological improvements are associated with improvements in clinical end points.
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