Journal ArticleDOI
Pulmonary atelectasis: a pathogenic perioperative entity.
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TLDR
The authors discuss the effects and implications of atelectasis in the perioperative period and illustrate how preventive measures may impact outcome and the impact of atElectasis and its prevention in acute lung injury.Abstract:
Atelectasis occurs in the dependent parts of the lungs of most patients who are anesthetized. Development of atelectasis is associated with decreased lung compliance, impairment of oxygenation, increased pulmonary vascular resistance, and development of lung injury. The adverse effects of atelectasis persist into the postoperative period and can impact patient recovery. This review article focuses on the causes, nature, and diagnosis of atelectasis. The authors discuss the effects and implications of atelectasis in the perioperative period and illustrate how preventive measures may impact outcome. In addition, they examine the impact of atelectasis and its prevention in acute lung injury.read more
Citations
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Journal ArticleDOI
Correlation of Lung Collapse and Gas Exchange - A Computer Tomographic Study in Sheep and Pigs with Atelectasis in Otherwise Normal Lungs
Samuel J. Wolf,Alexander P. Reske,Sören Hammermüller,Eduardo L. V. Costa,Peter M. Spieth,Pierre Hepp,Alysson R. Carvalho,Jens Kraßler,Hermann Wrigge,Marcelo B. P. Amato,Andreas W. Reske +10 more
TL;DR: In lung-healthy sheep and pigs, changes in atelectasis correlated strongly with corresponding changes in lnPaO2 and shunt, when blood gases are measured during ventilation with pure oxygen, and in humans, the observed relationships may aid in assessing anaesthesia-related atElectasis.
Journal ArticleDOI
Ventilation-Perfusion Relationship in Young Healthy Awake and Anesthetized-Paralyzed Man
TL;DR: The anatomic dead space was decreased and the alveolar dead space increased with induction of anesthesia-paralysis and intubation of the trachea, and lung units with low Va/Q or right-to-left intrapulmonary shunts developed.
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General Anesthesia Closes the Lungs: Keep Them Resting.
TL;DR: This work presents a novel and scalable approach that allows for real-time analysis of the response of the immune system to treat central giant cell granuloma.
Prediction, Prevention, and Treatment
TL;DR: Hypoxemia during OLV may be treatedsymptomatically by increasing inspired fraction of oxygen, byventilating, or by using continuous positive airway pressure inthe nonventilated lung.
Journal ArticleDOI
Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials.
Niklas Söderberg Campos,Thomas Bluth,Sabrine N.T. Hemmes,Julián Librero,Natividad Pozo,Carlos Ferrando,Lorenzo Ball,Guido Mazzinari,Paolo Pelosi,Marcelo Gama de Abreu,Marcus J. Schultz,Ary Serpa Neto +11 more
TL;DR: In this paper , the authors conducted a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery.
References
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Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
Roy G. Brower,Michael A. Matthay,Alan H. Morris,David A. Schoenfeld,B. Taylor Thompson,Arthur P. Wheeler +5 more
TL;DR: In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
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The acute respiratory distress syndrome
TL;DR: An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.
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Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome
Marcelo B. P. Amato,Carmen Silvia Valente Barbas,D Medeiros,R B Magaldi,Guilherme Schettino,Geraldo Lorenzi-Filho,Ronaldo Adib Kairalla,Daniel Deheinzelin,Carlos Munoz,Roselaine Pinheiro de Oliveira,Teresa Yae Takagaki,Carlos Roberto Ribeiro de Carvalho +11 more
TL;DR: As compared with conventional ventilation, the protective strategy was associated with improved survival at 28 days, a higher rate of weaning from mechanical ventilation, and a lower rate of barotrauma in patients with the acute respiratory distress syndrome.
Journal ArticleDOI
Ventilator-induced lung injury: lessons from experimental studies.
Didier Dreyfuss,Georges Saumon +1 more
TL;DR: This paper presents experimental evidence for Increased Vascular Transmural Pressure Evidence for Alterations in Alveolar–Capillary Permeability Contributions of the Static and Dynamic Lung Volume Components to Ventilator-induced Edema High-volume Lung Edema Low Lung Volume Injury.
Journal ArticleDOI
Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.
V. Marco Ranieri,Peter M. Suter,Cosimo Tortorella,Renato De Tullio,Jean-Michel Dayer,A. Brienza,Francesco Bruno,Arthur S. Slutsky +7 more
TL;DR: Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and recruitment/derecruitment of the lung, and these physiological improvements are associated with improvements in clinical end points.