Journal ArticleDOI
Pyrimidine Derivatives VIII: 5-Arylazopyrimidines and Their Inhibitory Effects against Transplantable Mouse Tumors
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TLDR
Twenty-five substituted 5-arylazopyrimidine derivatives have been prepared as potential “small molecule” antagonists of folic acid via reaction of 5-unsubstituted pyrim-idines with appropriate diazotized aniline derivatives and showed effective tumor growth inhibition, as evidenced by reduction in mean tumor size.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1966-06-01. It has received 11 citations till now. The article focuses on the topics: In vivo.read more
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Book ChapterDOI
Some pyrimidines of biological and medicinal interest. 3.
TL;DR: Pyrimidine derivatives have been found to possess fungicidal, antibacterial, antimitotic, antithyroid and surface-anaesthesia activities, with the exception of pyrimidine antibiotics.
Journal ArticleDOI
Waste-free chemistry of diazonium salts and benign separation of coupling products in solid salt reactions.
TL;DR: Gas-solid and solid-solid techniques allow for waste-free and quantitative syntheses in the chemistry of diazonium salts, and the solid-state reactions compare favourably with similar solution reactions that produce much waste.
Journal ArticleDOI
Computerized electronic spectral properties of some azobarbiturate compounds in presence of different solvents
TL;DR: In this article, the solvent effects on the spectra of 5-(p-substituted phenylazo) barbituric acid have been analyzed by the multiple linear regression technique using a Fortran IV program on a PC computer.
Patent
Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
F. George Njoroge,John J. Piwinski,Neng-Yang Shih,Cecil D. Kwong,Subramaniam Ananthan,Jeremy Clark,Feng Geng,Iii Hollis S. Kezar,Joseph A. Maddry,Robert C. Reynolds,Abhijit Roychowdhury,Iii John A. Secrist +11 more
TL;DR: In this paper, the authors provided compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of the compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22,
References
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Journal ArticleDOI
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
Sidney Farber,Diamond Lk +1 more
TL;DR: The occurrence of what the author interpreted as an "acceleration phenomenon" in the leukemic process as seen in the marrow and viscera of children with acute leukemia treated by the injection of folic acid conjugates1 and pteroyltriglutamic acid (teropterin) — and an experience gained from studies on folic .
Book
Experiments in organic chemistry
TL;DR: The first steps in safety practices in the organic chemistry laboratory are outlined in this paper and guidelines for notebooks are discussed. But safety practices are not discussed in detail in this paper.
Journal ArticleDOI
2,4-Diaminopyrimidines as Antimalarials. III. 5-Aryl Derivatives
Journal ArticleDOI
Biological studies of actinomycin d
TL;DR: In the summer of 1954, a preparation of actinomycin D, made available through the kindness of S. Waksman, was subjected to preliminary trial in the Mouse Bioassay Unit of The Children’s Cancer Research Foundation.
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