Journal ArticleDOI
Quality control of B-mode ultrasonic measurement of carotid artery intima-media thickness : the European lacidipine study on atherosclerosis
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TLDR
Cross-sectional and longitudinal quality control of the ultrasound measurements implemented throughout ELSA showed high reliability for all endpoints at all time points except for single maximum IMT (Tmax) and internal carotid IMT and within-reader reliability remained excellent.Abstract:
BackgroundThe European Lacidipine Study of Atherosclerosis (ELSA) was a prospective, randomized, double-blind, multinational interventional trial using B-mode ultrasound measurement of carotid intima–media thickness (IMT) in 2259 hypertensive individuals. ELSA showed that 4-year treatment with the cread more
Citations
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Journal ArticleDOI
Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine.
James H. Stein,Claudia E. Korcarz,R. Todd Hurst,Eva Lonn,Christopher B. Kendall,Emile R. Mohler,Samer S. Najjar,Christopher M. Rembold,Wendy S. Post +8 more
TL;DR: This activity describes the rationale for using carotid ultrasound to identify subclinical vascular disease and to evaluate cardiovascular disease risk, and explains the key components of interpreting carOTid ultrasound studies for cardiovascular Disease risk assessment.
Journal ArticleDOI
Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents: Recommendations for Standard Assessment for Clinical Research: A Scientific Statement From the American Heart Association
Elaine M. Urbina,Richard V. Williams,Bruce S. Alpert,Ronnie T. Collins,Stephen R. Daniels,Laura L. Hayman,Marc S. Jacobson,Larry T. Mahoney,Michele Mietus-Snyder,Albert P. Rocchini,Julia Steinberger,Brian W. McCrindle +11 more
TL;DR: This scientific statement was written to review the current literature on the noninvasive assessment of atherosclerosis in children and adolescents, make recommendations for the standardization of these tools for research, and stimulate further research with a goal of developing valid and reliable techniques with normative data for nonin invasive clinical evaluation of atheosclerosis in Pediatrics.
Journal ArticleDOI
Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study.
Carl Grunfeld,Joseph A.C. Delaney,Christine Wanke,Judith S. Currier,Rebecca Scherzer,Mary L. Biggs,Phyllis C. Tien,Michael G. Shlipak,Stephen Sidney,Joseph F. Polak,Daniel H. O'Leary,Peter Bacchetti,Richard A. Kronmal +12 more
TL;DR: The stronger association of HIV infection with IMT in the internal/bulb region compared with the common carotid may explain previous discrepancies in the literature and was similar to that of traditional CVD risk factors, such as smoking.
Journal ArticleDOI
Visit-to-Visit Blood Pressure Variability, Carotid Atherosclerosis and Cardiovascular Events in the European Lacidipine Study on Atherosclerosis
TL;DR: In mildly to moderately hypertensive patients, carotid intima-media thickness and cardiovascular outcomes were related to the mean clinic or ambulatory SBP achieved by treatment but not to on-treatment visit-to-visit clinic or 24-hour BP variability, suggesting inconsistency of BP control between visits plays a less important prognostic role than long-term average BP levels.
Journal ArticleDOI
Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: findings in the European Lacidipine Study on Atherosclerosis (ELSA).
Alberto Zanchetti,M. Hennig,Regina Hollweck,Gene Bond,Rong Tang,Cesare Cuspidi,Gianfranco Parati,Rita Facchetti,Giuseppe Mancia +8 more
TL;DR: ELSA shows that carotid intima-media thickening and plaques are important added risks of cardiovascular outcomes in a treated hypertensive population independently of blood pressure and traditional risk factors, but the analysis failed to show a predictive role of treatment-dependent IMT changes.
References
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Journal ArticleDOI
Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid Atherosclerosis Principal Results of the European Lacidipine Study on Atherosclerosis (ELSA), a Randomized, Double-Blind, Long-Term Trial
Alberto Zanchetti,M. Gene Bond,M. Hennig,Albrecht Neiss,Giuseppe Mancia,Cesare Dal Palù,Lennart Hansson,Bruno Magnani,Karl Heinz Rahn,John L. Reid,Jose L. Rodicio,Michel E. Safar,Lothar Eckes,Paolo Rizzini +13 more
TL;DR: The greater efficacy of lacidipine on carotid IMT progression and number of plaques per patient, despite a smaller ambulatory blood pressure reduction, indicates an antiatherosclerotic action of lacIDipine independent of its antihypertensive action.
Journal ArticleDOI
Final Outcome Results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS): A Randomized Controlled Trial
Nemat O. Borhani,Michele Mercuri,Patricia A. Borhani,Vardaman M. Buckalew,Maria Canossa-Terris,Albert A. Carr,Tissa Kappagoda,Michael V. Rocco,Harold W. Schnaper,James R. Sowers,M. Gene Bond +10 more
TL;DR: The rate of progression of mean maximum IMT in carotid arteries, the surrogate end point in this study, did not differ between the 2 treatment groups, and the increased incidence of vascular events in patients receiving isradipine compared with hydrochlorothiazide is of concern.
Journal ArticleDOI
Risk Factors for Progression of Common Carotid Atherosclerosis: The Atherosclerosis Risk in Communities Study, 1987–1998
Lloyd E. Chambless,Aaron R. Folsom,Vicki G. Davis,Richey Sharrett,Gerardo Heiss,Paul D. Sorlie,Moyses Szklo,George Howard,Gregory W. Evans +8 more
TL;DR: In this paper, the authors examined the association of baseline risk factors or change in risk factors with change in intima-media thickness over follow-up (1987-1998) in the Atherosclerosis Risk in Communities (ARIC) population-based cohort (baseline: age 45-64 years, n = 15,792).
Journal ArticleDOI
Risk factors associated with alterations in carotid-intima-media thickness in hypertension: baseline data from the European lacidipine study on atherosclerosis
Alberto Zanchetti,Bond Mg,M. Hennig,Neiss A,Giuseppe Mancia,Dal Palù C,L. Hansson,Bruno Magnani,Karl Heinz Rahn,JL Reid,Jose L. Rodicio,M. E. Safar,Lothar Eckes,Ravinetto R +13 more
TL;DR: Analysis of baseline data from the ELSA has shown that there is an extremely marked prevalence of carotid artery wall alterations among mild-to-moderate, middle-aged hypertensive patients, and significant correlations between ultrasound measurements and the following demographic and clinical variables.
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Pierre-Jean Touboul,M.G. Hennerici,Stephen Meairs,Harold P. Adams,Pierre Amarenco,N. M. Bornstein,László Csiba,M. Desvarieux,Shah Ebrahim,Marc Fatar,R. Hernandez Hernandez,Michael R. Jaff,S. Kownator,Patrizio Prati,Tatjana Rundek,Matthias Sitzer,Ulf Schminke,J.-C. Tardif,A. Taylor,Eric Vicaut,K.S. Woo,Faiez Zannad,Mahmoud Zureik +22 more