Journal ArticleDOI
Quality of life after acute respiratory distress syndrome: a meta-analysis
David W. Dowdy,Mark P. Eid,Cheryl R. Dennison,Pedro A. Mendez-Tellez,Margaret S. Herridge,Eliseo Guallar,Peter J. Pronovost,Dale M. Needham +7 more
Reads0
Chats0
TLDR
ARDS survivors in different clinical settings experience similar decrements in QOL, and the precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors.Abstract:
To summarize long-term quality of life (QOL) and the degree of variation in QOL estimates across studies of acute respiratory distress (ARDS) survivors.
A systematic review of studies evaluating QOL in ARDS survivors was conducted. Medline, EMBASE, CINAHL, pre-CINAHL, and the Cochrane Library were searched, and reference lists from relevant articles were evaluated. Two authors independently selected studies reporting QOL in adult survivors of ARDS or acute lung injury at least 30 days after intensive care unit discharge and extracted data on study design, patient characteristics, methods, and results. Thirteen independent observational studies (557 patients) met inclusion criteria. Eight of these studies used eight different QOL instruments, allowing only qualitative synthesis of results. The five remaining studies (330 patients) measured QOL using the Medical Outcomes Study 36-Item Short Form survey (SF-36). Mean QOL scores were similar across these studies, falling within a range of 20 points for all domains. Pooled domain-specific QOL scores in ARDS survivors 6 months or later after discharge ranged from 45 (role physical) to 66 (social functioning), or 15–26 points lower than population norms, in all domains except mental health (11 points) and role physical (39 points). Corresponding confidence intervals were no wider than ± 9 points. Six studies all found stable or improved QOL over time, but only one found significant improvement beyond 6 months after discharge. ARDS survivors in different clinical settings experience similar decrements in QOL. The precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors.read more
Citations
More filters
Journal ArticleDOI
Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference.
Dale M. Needham,Judy E. Davidson,Henry Cohen,Ramona O. Hopkins,Craig R. Weinert,Hannah Wunsch,Christine Zawistowski,Anita Bemis-Dougherty,Susan C Berney,O. Joseph Bienvenu,Susan Brady,Martin B. Brodsky,Linda Denehy,Doug Elliott,Carl Flatley,Andrea L. Harabin,Christina Jones,Deborah Louis,Wendy Meltzer,Sean R. Muldoon,Jeffrey B. Palmer,Christiane Perme,Marla Robinson,David M. Schmidt,Elizabeth Scruth,Gayle R. Spill,C. Porter Storey,Marta L. Render,John Votto,Maurene A. Harvey +29 more
TL;DR: Improving care for intensive care survivors and their families requires collaboration between practitioners and researchers in both the inpatient and outpatient settings, and three major themes emerged from the conference.
Journal ArticleDOI
Long-term complications of critical care
TL;DR: Survivors of critical illness are frequently left with a legacy of long-term physical, neuropsychiatric, and quality of life impairments, which can help identify patients who are most at risk of these complications.
Journal ArticleDOI
Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project.
Dale M. Needham,Radha Korupolu,Jennifer M. Zanni,Pranoti Pradhan,Elizabeth Colantuoni,Jeffrey B. Palmer,Roy G. Brower,Eddy Fan +7 more
TL;DR: Using a quality improvement process, intensive care unit delirium, physical rehabilitation, and functional mobility were markedly improved and associated with decreased length of stay.
Journal ArticleDOI
Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment
TL;DR: Phase III clinical trials by the NHLBI ARDS Network have resulted in improvement in survival and a reduction in the duration of mechanical ventilation with a lung-protective ventilation strategy and fluid conservative protocol, potential areas of future treatments include nutritional strategies, statin therapy, and mesenchymal stem cells.
Journal ArticleDOI
Long-term mortality and quality of life in sepsis: a systematic review.
Bradford D. Winters,Michael Eberlein,Janice Leung,Dale M. Needham,Peter J. Pronovost,Jonathan E. Sevransky +5 more
TL;DR: Patients with sepsis have ongoing mortality beyond short-term end points, and survivors consistently demonstrate impaired quality of life, and the use of 28-day mortality as an end point for clinical studies may lead to inaccurate inferences.
References
More filters
Journal ArticleDOI
The measurement of observer agreement for categorical data
J. R. Landis,Gary G. Koch +1 more
TL;DR: A general statistical methodology for the analysis of multivariate categorical data arising from observer reliability studies is presented and tests for interobserver bias are presented in terms of first-order marginal homogeneity and measures of interob server agreement are developed as generalized kappa-type statistics.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal Article
EuroQol : a new facility for the measurement of health-related quality of life
Journal ArticleDOI
The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination
Gordon R. Bernard,Antonio Artigas,Kenneth L. Brigham,J. Carlet,K. Falke,L. Hudson,M. Lamy,J. R. LeGall,Alan H. Morris,Roger G. Spragg +9 more
TL;DR: The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.