Journal ArticleDOI
Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection.
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This article is published in Journal of Chromatography B: Biomedical Sciences and Applications.The article was published on 1988-01-01. It has received 71 citations till now. The article focuses on the topics: High-performance liquid chromatography.read more
Citations
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Journal ArticleDOI
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Melvyn P. Heyes,Kuniaki Saito,Jeffrey S. Crowley,L. E. Davis,M. A. Demitrack,M. Der,L. A. Dilling,J. Elia,M. J. P. Kruesi,Andrew A. Lackner,S. A. Larsen,K. Lee,H. L. Leonard,Sanford P. Markey,Alex Martin,S. Milstein,M. Maral Mouradian,M. R. Pranzatelli,Bonnie J. Quearry,Andres M. Salazar,M. Smith,S. E. Strauss,T. Sunderland,S. W. Swedo,W. W. Tourtellotte +24 more
TL;DR: It is concluded that inflammatory diseases are associated with accumulation of QUIN, kynurenic acid and L-kynurenine within the central nervous system, but that the available data do not support a role for QUIN in the aetiology of Huntington's disease or Alzheimer's disease.
Journal ArticleDOI
Increased cortical kynurenate content in schizophrenia.
Robert Schwarcz,Arash Rassoulpour,Hui Qiu Wu,Deborah R. Medoff,Carol A. Tamminga,Rosalinda C. Roberts +5 more
TL;DR: In rats, chronic treatment with haloperidol did not cause an increase in kynurenate levels in the frontal cortex, indicating that the elevation observed in schizophrenia is not due to antipsychotic medication.
Journal ArticleDOI
Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid.
TL;DR: Because kynurenic acid is an endogenous inhibitor of excitatory neurotransmission and can block excitotoxic degeneration in vivo, a relative deficiency of this compound could directly contribute to neuronal degenerations in HD.
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Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia
Korrapati V. Sathyasaikumar,Erin K. Stachowski,Ikwunga Wonodi,Rosalinda C. Roberts,Rosalinda C. Roberts,Arash Rassoulpour,Robert P. McMahon,Robert Schwarcz +7 more
TL;DR: The present results further support the hypothesis that the normalization of cortical KP metabolism may constitute an effective new treatment strategy in SZ.
Journal ArticleDOI
Kynurenine and its metabolites in Alzheimer's disease patients
TL;DR: Examination of peripheral KP in patients with Alzheimer type dementia proves activation of peripheral kynurenine pathway in this type of dementia and offers Novel therapeutic opportunities, with the development of new compounds as a promising perspective for brain neuroprotection.
References
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Journal ArticleDOI
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid
TL;DR: It is proposed that an aspartergic component may contribute to the development of convulsions after 3MPA, TSC, DMCM and picrotoxin.
Journal ArticleDOI
SYNTHESIS AND METABOLISM OF l‐KYNURENINE IN RAT BRAIN
E. M. Gál,A. D. Sherman +1 more
TL;DR: Kynurenine was formed from tryptophan in brain and was also taken up from the periphery, and kynuramine levels in different areas of the brain were similar to those of tryptamine.
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Convulsant action of intracerebroventricularly administered l-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships
TL;DR: Succinic acid, and the derivatives which have been tested, as well as l-kynurenine sulphate and quinolinic acid, injected into the brain ventricles in mice, induced clonic seizures.
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Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography.
Samuel Yong,Susan Lau +1 more
Journal ArticleDOI
Effects of vitamin B-6 deficiency and tryptophan loading on urinary excretion of tryptophan metabolites in mammals
James K. Yeh,Raymond R. Brown +1 more
TL;DR: Levels of urinary metabolites reached a maximum in guinea pigs after only 1 week of consuming the vitamin B-6 deficient diet, suggesting that the vitamin deficiency developed very rapidly in this species.