Radial glia serve as neuronal progenitors in all regions of the central nervous system.
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It is shown that the vast majority of neurons in all brain regions derive from radial glia, and that radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.About:
This article is published in Neuron.The article was published on 2004-03-25 and is currently open access. It has received 793 citations till now. The article focuses on the topics: Radial glial cell & Neurogenesis.read more
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The glial nature of embryonic and adult neural stem cells
TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
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The cell biology of neurogenesis.
TL;DR: In this paper, the authors discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.
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Neuronal subtype specification in the cerebral cortex.
TL;DR: Recent data regarding the nature of neocortical progenitors is assessed, the roles of individual genes in projection neuron specification are reviewed and the implications for progenitor plasticity are discussed.
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The cell biology of neurogenesis
TL;DR: This work discusses how features of epithelial characteristics change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.
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GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
TL;DR: These findings identify morphologically distinctive GFAP-expressing progenitor cells as the predominant sources of constitutive adult neurogenesis, and provide new methods for manipulating and investigating these cells.
References
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Book
Manipulating the mouse embryo: A laboratory manual
TL;DR: Here are recorded the tech- niques for preparing, inserting and analysing DNA sequences, for retroviral infection of mice, for production and use of EC and EK cells as vehicles for engineered sequences and for nuclear transplantation - all against a background of the basic procedures required for pro- ducing and handling the em- bryos.
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Mode of cell migration to the superficial layers of fetal monkey neocortex.
TL;DR: Golgi and electronmicroscopic methods were used to define the shapes and intercellular relationships of cells migrating from their sites of origin near the ventricular surface across the intermediate zone to the superficial neocortical layers of the parietooccipital region in the brains of 75‐ to 97‐day monkey fetuses.
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Neurons derived from radial glial cells establish radial units in neocortex
Stephen C. Noctor,Alexander C. Flint,Tamily A. Weissman,Ryan S. Dammerman,Arnold R. Kriegstein +4 more
TL;DR: The results support the concept that a lineage relationship between neurons and proliferative radial glia may underlie the radial organization of neocortex.
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Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse.
J. B. Angevine,Richard L. Sidman +1 more
TL;DR: When the autoradiographic method is applied to tissues of animals killed serially, one can determine the time and place of origin of cells, their route and rate of migration, and their ultimate fate.