Journal ArticleDOI
Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group.
David G. Jayne,Pierre J. Guillou,H. Thorpe,Philip Quirke,Joanne Copeland,Adrian Smith,Richard M. Heath,Julia Brown +7 more
TLDR
Long-term outcomes for patients with rectal cancer were similar in those undergoing abdominoperineal resection and AR, and support the continued use of laparoscopic surgery in these patients.Abstract:
Purpose The aim of the current study is to report the long-term outcomes after laparoscopic-assisted surgery compared with conventional open surgery within the context of the UK MRC CLASICC trial. Results from randomized trials have indicated that laparoscopic surgery for colon cancer is as effective as open surgery in the short term. Few data are available on rectal cancer, and long-term data on survival and recurrence are now required. Methods The United Kingdom Medical Research Council Conventional versus Laparoscopic-Assisted Surgery in Colorectal Cancer (UK MRC CLASICC; clinical trials number ISRCTN 74883561) trial study comparing conventional versus laparoscopic-assisted surgery in patients with cancer of the colon and rectum. The randomization ratio was 2:1 in favor of laparoscopic surgery. Long-term outcomes (3-year overall survival [OS], disease-free survival [DFS], local recurrence, and quality of life [QoL]) have now been determined on an intention-to-treat basis. Results Seven hundred ninety-f...read more
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Guidelines for perioperative care in elective colonic surgery: Enhanced recovery after surgery (ERAS®) society recommendations
Ulf Gustafsson,Michael J. Scott,Michael J. Scott,W. Schwenk,Nicolas Demartines,Didier Roulin,Nader K. Francis,Clare McNaught,John MacFie,A. S. Liberman,Mattias Soop,Andrew G. Hill,Robin H. Kennedy,Dileep N. Lobo,Kenneth C. H. Fearon,Olle Ljungqvist,Olle Ljungqvist +16 more
TL;DR: Based on the evidence available for each item of the multimodal perioperative care pathway, the Enhanced Recovery After Surgery (ERAS) Society, International Association for Surgical Metabolism and Nutrition (IASMEN) and European Society for Clinical Nutrition and Metabolicism (ESPEN) present a comprehensive evidence-based consensus review of peri operative care for colonic surgery.
Journal ArticleDOI
Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
Journal ArticleDOI
Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial
Martijn H G M van der Pas,Eva Haglind,Miguel A. Cuesta,Alois Fürst,Antonio M. Lacy,Wim C. J. Hop,Hendrik J. Bonjer +6 more
TL;DR: In selected patients with rectal cancer treated by skilled surgeons, laparoscopic surgery resulted in similar safety, resection margins, and completeness of resection to that of open surgery, and recovery was improved after laparoscope surgery.
Journal ArticleDOI
Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial.
M. Buunen,R. Veldkamp,Wim C. J. Hop,Esther Kuhry,Johannes Jeekel,Eva Haglind,Lars Påhlman,Miguel A. Cuesta,Simon Msika,Mario Morino,Antonio M. Lacy,Hendrik J. Bonjer +11 more
TL;DR: The trial could not rule out a difference in disease-free survival at 3 years in favour of open colectomy because the upper limit of the 95% CI for the difference just exceeded the predetermined non-inferiority boundary of 7%, but, it believes, clinically acceptable, justifying the implementation of laparoscopic surgery into daily practice.
Journal ArticleDOI
A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer
H. Jaap Bonjer,Charlotte L. Deijen,Gabor S. A. Abis,Miguel A. Cuesta,Lange-de Klerk,Antonio M. Lacy,Willem A. Bemelman,John Andersson,Eva Angenete,Jacob Rosenberg,Alois Fuerst,Eva Haglind +11 more
TL;DR: Laroscopic surgery in patients with rectal cancer was associated with rates of locoregional recurrence and disease-free and overall survival similar to those for open surgery.
References
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The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
Neil K. Aaronson,Sam H Ahmedzai,Bengt Bergman,Monika Bullinger,Ann Cull,Nicole Duez,Antonio Filiberti,Henning Flechtner,Stewart B. Fleishman,Johanna C. J. M. de Haes,Stein Kaasa,M. Klee,David Osoba,Darius Razavi,Peter B. Rofe,Simon Schraub,Kommer C. A. Sneeuw,Marianne Sullivan,Fumikazu Takeda +18 more
TL;DR: The reliability and validity of the EORTC QLQ-C30 questionnaire were highly consistent across the three language-cultural groups studied: patients from English-speaking countries, Northern Europe, and Southern Europe.
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A comparison of laparoscopically assisted and open colectomy for colon cancer.
Heidi Nelson,Daniel J. Sargent,H Sam Wieand,James W. Fleshman,Mehran Anvari,Steven J. Stryker,Robert W. Beart,Michael D. Hellinger,Richard Flanagan,Walter R. Peters,David M. Ota +10 more
TL;DR: In this multi-institutional study, the rates of recurrent cancer were similar after laparoscopically assisted colectomy and open-colectomy, suggesting that the laparoscopic approach is an acceptable alternative to open surgery for colon cancer.
Journal ArticleDOI
Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial
Pierre J. Guillou,Philip Quirke,H. Thorpe,J. Walker,David G. Jayne,Adrian Smith,Richard M. Heath,Julia Brown +7 more
TL;DR: Laroscopic-assisted surgery for cancer of the colon is as effective as open surgery in the short term and is likely to produce similar long-term outcomes, however, impaired short- term outcomes after laparosc-assisted anterior resection forcancer of the rectum do not yet justify its routine use.
Journal ArticleDOI
Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial
Antonio M. Lacy,Juan Carlos García-Valdecasas,Salvadora Delgado,Antoni Castells,Pilar Taura,Josep M. Piqué,Josep Visa +6 more
TL;DR: LAC is more effective than OC for treatment of colon cancer in terms of morbidity, hospital stay, tumour recurrence, and cancer-related survival.
Journal ArticleDOI
Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial.
R. Veldkamp,Esther Kuhry,Wim C. J. Hop,Johannes Jeekel,Geert Kazemier,Hendrik J. Bonjer,Eva Haglind,Lars Påhlman,Miguel A. Cuesta,Simon Msika,M. Morino,Antonio M. Lacy +11 more
TL;DR: Laroscopic colectomy was associated with earlier recovery of bowel function, need for fewer analgesics, and with a shorter hospital stay compared with open colectology.