Journal ArticleDOI
Rapid prototyping of tissue-engineering constructs, using photopolymerizable hydrogels and stereolithography.
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TLDR
In this paper, a commercially available stereolithography technique was applied to fabricate scaffolds using poly(ethylene oxide) and poly (ethylene glycol)dimethacrylate photopolymerizable hydrogels.Abstract:
One of the most important aspects of tissue engineering is the design of the scaffold providing the mechanical strength and access to nutrients for the new tissue. For customized tissue engineering, it is essential to be able to fabricate three-dimensional scaffolds of various geometric shapes, in order to repair defects caused by accidents, surgery, or birth. Rapid prototyping or solid free-form fabrication (SFF) techniques hold great promise for designing three-dimensional customized scaffolds, yet traditional cell-seeding techniques may not provide enough cell mass for larger constructs. This article presents a novel attempt to fabricate three-dimensional scaffolds, using hydrogels combined with cell encapsulation to fabricate high-density tissue constructs. A commercially available stereolithography technique was applied to fabricate scaffolds using poly(ethylene oxide) and poly(ethylene glycol)dimethacrylate photopolymerizable hydrogels. Mechanical characterization shows the constructs to be comparable with soft tissues in terms of elasticity. High cell viability was achieved and high-density constructs fabricated.read more
Citations
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Journal ArticleDOI
Porous scaffold design for tissue engineering
TL;DR: The integration of CTD with SFF to build designer tissue-engineering scaffolds is reviewed and the mechanical properties and tissue regeneration achieved using designer scaffolds are details.
Journal ArticleDOI
Three-dimensional scaffolds for tissue engineering applications : role of porosity and pore size
Qiu Li Loh,Cleo Choong +1 more
TL;DR: The ability of pore size and porosity of scaffolds to direct cellular responses and alter the mechanical properties of scaffold will be reviewed, followed by a look at nature's own scaffold, the extracellular matrix.
Journal ArticleDOI
A review on stereolithography and its applications in biomedical engineering
TL;DR: Stereolithography is a solid freeform technique (SFF) that was introduced in the late 1980s as mentioned in this paper, and it has been widely used in biomedical applications, as well as the biodegradable resin materials developed for use with stereolithography.
Journal ArticleDOI
Additive manufacturing: technology, applications and research needs
Nannan Guo,Ming-Chuan Leu +1 more
TL;DR: Additive manufacturing (AM) technology has been researched and developed for more than 20 years as mentioned in this paper, and significant progress has been made in the development and commercialization of new and innovative AM processes, as well as numerous practical applications in aerospace, automotive, biomedical, energy and other fields.
Journal ArticleDOI
Scaffolding in tissue engineering: general approaches and tissue-specific considerations.
Barbara P. Chan,K. W. Leong +1 more
TL;DR: The functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds are reviewed and the tissue-specific considerations for scaffolding are discussed, using intervertebral disc as an example.
References
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Journal ArticleDOI
The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors
TL;DR: The authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods.
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Fused deposition modeling of novel scaffold architectures for tissue engineering applications.
TL;DR: Analysis of the measured data shows a high correlation between the scaffold porosity and the compressive properties based on a power-law relationship.
Journal ArticleDOI
Photopolymerizable hydrogels for tissue engineering applications.
Kytai T. Nguyen,Jennifer L. West +1 more
TL;DR: Advantages of photopolymerization of hydrogels are presented, the photoinitiators and materials in current use are described and the applications that have been investigated are summarized.
Journal ArticleDOI
Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems
TL;DR: The application, advancement and future directions of SFF techniques in the design and creation of scaffolds for use in clinically driven tissue engineering are reviewed.
Journal ArticleDOI
Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs.
TL;DR: This paper identifies essential structural characteristics and the pre-requisites for fabrication techniques that can yield scaffolds that are capable of directing healthy and homogeneous tissue development and compares the advantages and limitations of the SFF techniques.