Reactive oxygen species and rat renal epithelial cells during hypoxia and reoxygenation.
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TLDR
It is demonstrated that proximal tubule epithelial cells produce reactive oxygen species in increased amounts during hypoxia and reoxygenation, and that these reactive oxygenspecies are injurious to the cells under these conditions.About:
This article is published in Kidney International.The article was published on 1991-12-01 and is currently open access. It has received 142 citations till now. The article focuses on the topics: Reactive oxygen species & Superoxide dismutase.read more
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Journal ArticleDOI
Reactive species mechanisms of cellular hypoxia-reoxygenation injury.
TL;DR: This review focuses on the specific roles of ROS and RNS in the cellular response to hypoxia and subsequent cytolytic injury during reoxygenation.
Journal ArticleDOI
Reactive oxygen species and acute renal failure
Karl A. Nath,Suzanne M. Norby +1 more
TL;DR: Evidence indicating that the inordinate or aberrant generation of reactive oxygen species (ROS) may contribute to the initiation and maintenance of ATN is reviewed, and the possibility that ROS may participate in the recovery phase of ATn is raised.
Journal ArticleDOI
In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity
Radhakrishna Baliga,Zhiwei Zhang,Zhiwei Zhang,Zhiwei Zhang,Mithra Baliga,Mithra Baliga,Mithra Baliga,Norishi Ueda,Norishi Ueda,Norishi Ueda,Sudhir V. Shah,Sudhir V. Shah,Sudhir V. Shah +12 more
TL;DR: The data strongly support a critical role for iron in mediating tissue injury via hydroxyl radical (or a similar oxidant) in this model of nephrotoxicity.
Journal ArticleDOI
Renal ischaemia-reperfusion injury
TL;DR: It appears that relatively less importance should be attached to the involvement of neutrophils at isocheimal‐reperfusion sites, and relatively more to a local postiischaemic imbalance in the levels of nitric oxide and endothelin.
Journal ArticleDOI
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
Marina Morigi,Daniela Macconi,Carla Zoja,Roberta Donadelli,Simona Buelli,Cristina Zanchi,Marina Ghilardi,Giuseppe Remuzzi +7 more
TL;DR: Exposure to excess proteins in proximal tubular cells induces the formation of ROS, which is responsible for NF-kappaB activation and consequent induction of NF- kappaB-dependent inflammatory signals, according to real-time PCR data.
References
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Oxygen-derived free radicals in postischemic tissue injury.
TL;DR: It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
Journal ArticleDOI
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
Alberto Boveris,Britton Chance +1 more
TL;DR: It is postulated that in addition to the well-known flavin reaction, formation of H( 2)O(2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level.
Journal Article
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
David A. Bass,J W Parce,Lawrence R. DeChatelet,Pamela Szejda,Michael C. Seeds,Michael J. Thomas +5 more
TL;DR: The data indicate that the DCFH oxidation assay is quantitatively related to the oxidative metabolic burst of PMNL, and they strongly suggest that the reaction is mediated by H2O2 generated by the PMNL.
Book
Free radical mechanisms in tissue injury
TL;DR: This short review of free radicals discusses certain types of free radical, such as nitroxyl-radicals and free radicals stabilized by steric or derealization features, which are stable enough to be crystallised and stored at temperatures above 0°.