Journal ArticleDOI
Recent Advances in Catalytic, Enantioselective α Aminations and α Oxygenations of Carbonyl Compounds
TLDR
A synopsis of this ever-growing field of catalytic, enantioselective Lewis acid and Lewis base catalysis is provided and some of the challenges that still remain are highlighted.Abstract:
The direct introduction of either a nitrogen or oxygen atom adjacent to a carbonyl group in a catalytic, enantioselective manner using both chiral Lewis acid and Lewis base catalysis has been described recently. The enantiomerically enriched products of these reactions, such as α-amino acids, represent fundamental building blocks for the construction of complex natural products and other important bioactive molecules. This Minireview provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.read more
Citations
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Journal ArticleDOI
Visible-Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
TL;DR: This Review compares classical and photocatalytic procedures for selected classes of reactions and highlights their advantages and limitations.
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Asymmetric aminocatalysis--gold rush in organic chemistry.
TL;DR: This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development.
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Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update
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Catalytic Asymmetric Synthesis of α-Amino Acids
Carmen Nájera,José M. Sansano +1 more
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Recent development of direct asymmetric functionalization of inert C–H bonds
Chao Zheng,Shu-Li You +1 more
TL;DR: The area of direct asymmetric functionalization of inert C-H bonds has attracted considerable attention in recent years as discussed by the authors, and a lot of strategies have emerged including asymmetric C−H bond insertion by metal carbenoids or analogs, cross dehydrogenative coupling, [1,5]-hydride transfer, C-h bond functionalization involving a transient metal-carbon species and other miscellaneous methods.
References
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Journal ArticleDOI
In the Golden Age of Organocatalysis
Peter I. Dalko,Lionel Moisan +1 more
TL;DR: The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose "Golden Age" has already dawned.
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Chiral bis(oxazoline) copper(II) complexes: versatile catalysts for enantioselective cycloaddition, Aldol, Michael, and carbonyl ene reactions.
TL;DR: X-ray crystallography of the chiral complexes reveals a propensity for the formation of distorted square planar or square pyramidal geometries in catalyzed processes that exhibit excellent temperature-selectivity profiles.
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Enamine catalysis is a powerful strategy for the catalytic generation and use of carbanion equivalents.
TL;DR: Contributions from this laboratory to the revitalized interest in asymmetric enamine catalysis are summarized in this Account.
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Im Goldenen Zeitalter der Organokatalyse
Peter I. Dalko,Lionel Moisan +1 more
TL;DR: In this article, the authors show that bekannten organokatalytischen Reaktionen sind bezuglich ihrer Effizienz und Selektivitat with etablierten organischen Verbindungen vergleichbar, and die Organokataliase hat sich beim Aufbau komplexer Molekulgeruste bewahrt.
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Asymmetric hydroxylation of enolates with N-sulfonyloxaziridines
Franklin A. Davis,Bang Chi Chen +1 more
TL;DR: Davis as discussed by the authors was a pioneer in asymmetric synthesis, and developed a new method for stereoselective fluorination of organic molecules, which is a recent focus of his research at Drexel University.