Journal ArticleDOI
Recent advances in the biochemistry and clinical relevance of the isoprostane pathway.
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TLDR
The complexity of the IsoP pathway has expanded, providing novel insights into mechanisms of lipid peroxidation in vivo and allowing investigators to explore the role of oxidative stress in human disease.Abstract:
Isoprostanes (IsoPs), lipid peroxidation products formed via the free radical-mediated oxidation of arachidonic acid, have become the "gold standard" biomarker of oxidative stress in vivo over the past 15 yr. Significant advances have been made in understanding this important pathway of lipid peroxidation. Recent studies from our laboratory are discussed that have provided insights into the mechanism of formation and regioisomeric distribution of these compounds and that have identified novel products of the IsoP pathway such as cyclized dioxolane IsoPs, IsoP-derived racemic prostaglandins, and reactive cyclopentenone IsoP, the latter of which possess potent biological actions. Furthermore, new independent studies have demonstrated that IsoPs are the most reliable available marker of lipid peroxidation in vivo, and recent work examining IsoP formation has provided valuable information about the pathogenesis of numerous human diseases. Thus, the complexity of the IsoP pathway has expanded, providing novel insights into mechanisms of lipid peroxidation in vivo and allowing investigators to explore the role of oxidative stress in human disease.read more
Citations
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Biological markers of oxidative stress: Applications to cardiovascular research and practice.
Edwin Ho,Keyvan Karimi Galougahi,Keyvan Karimi Galougahi,Chia-Chi Liu,Ravi Bhindi,Ravi Bhindi,Gemma A. Figtree,Gemma A. Figtree +7 more
TL;DR: Functional significance of the oxidative modifications enhances their validity as a proposed biological marker of cardiovascular disease, and is the strength of the redox cysteine modifications such as glutathionylation.
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Oxidative stress and male infertility
TL;DR: Lifestyle interventions including yoga and meditation can substantially improve the integrity of sperm DNA by reducing levels of oxidative DNA damage, regulating oxidative stress and by increasing the expression of genes responsible for DNA repair, cell-cycle control and anti-inflammatory effects.
Journal ArticleDOI
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs
TL;DR: A detailed compilation of the main oxylipins formed from PUFAs is provided and the understanding of the differing biological potencies, kinetics, and isomer-specific activities of these novel PUFA metabolites is described.
Journal ArticleDOI
Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.
TL;DR: By comparing results obtained at different stages of the AD, it may be possible to identify key biochemical pathways involved and ideally identify therapeutic targets to prevent, delay, or treat AD.
References
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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
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