Journal ArticleDOI
Recent advances in the synthesis of biologically active spirooxindoles
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This article is published in Tetrahedron.The article was published on 2014-12-30. It has received 316 citations till now.read more
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Deep Eutectic Solvents: The Organic Reaction Medium of the Century
Diego A. Alonso,Alejandro Baeza,Rafael Chinchilla,Gabriela Guillena,Isidro M. Pastor,Diego J. Ramón +5 more
TL;DR: The use of deep eutectic solvents (DESs) and related melts in organic synthesis is summarized in this paper, where the authors present a review of the state of the art and great opportunities opened for academic purposes and also for industry.
Journal ArticleDOI
Catalytic asymmetric synthesis of spirooxindoles: recent developments
Guang-Jian Mei,Feng Shi +1 more
TL;DR: This feature article outlines the recent progress in the catalytic asymmetric synthesis of spirooxindoles, including the contributions of the group of scientists from the University of California, Berkeley.
Journal ArticleDOI
Deep eutectic solvents (DESs) as eco-friendly and sustainable solvent/catalyst systems in organic transformations
TL;DR: In this article, the use of environmentally benign and inexpensive eutectic solvents (DESs) as solvent and catalyst in the field of organic chemistry is discussed and compared.
Journal ArticleDOI
An overview of spirooxindole as a promising scaffold for novel drug discovery.
TL;DR: An overview of different applications and developments of spirooxindoles (including the related natural products and their derivatives) in the process of drug innovation, including such as in anticancer, antimicrobial, anti–inflammatory, analgesic, antioxidant, antimalarial, and antiviral activities is offered.
Journal ArticleDOI
Stereoselective synthesis and applications of spirocyclic oxindoles
Alexander J. Boddy,James A. Bull +1 more
TL;DR: In this paper, the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3-to 8-membered rings is discussed.
References
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Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
TL;DR: The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
Journal ArticleDOI
Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks
Journal ArticleDOI
Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position
Feng Zhou,Yun-Lin Liu,Jian Zhou +2 more
TL;DR: The catalytic asymmetric synthesis of the tetrasubstituted carbon stereocenter at the C-3 position of the oxindole framework integrates new synthetic methods and chiral catalysts.
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Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Matthias Rottmann,Matthias Rottmann,Case W. McNamara,Bryan K. S. Yeung,Marcus C. S. Lee,Bin Zou,Bruce Russell,Bruce Russell,Patrick Seitz,Patrick Seitz,David Plouffe,Neekesh V. Dharia,Jocelyn Tan,Steven Cohen,Kathryn S. R. Spencer,Gonzalo E. González-Páez,Suresh B. Lakshminarayana,Anne Goh,Rossarin Suwanarusk,Timothy Jegla,Esther K. Schmitt,Hans-Peter Beck,Hans-Peter Beck,Reto Brun,Reto Brun,François Nosten,François Nosten,Laurent Rénia,Véronique Dartois,Thomas H. Keller,David A. Fidock,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Thierry T. Diagana +33 more
TL;DR: The preclinical profile for an optimized spiroindolone drug candidate, NITD609, shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model.
Journal ArticleDOI
Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies
TL;DR: This review focuses on the enantioselective synthesis of spirooxindoles via organocascade strategies and is organized on the basis of three primary starting materials and then further subdivided according to the types of organocatalyst.