Journal ArticleDOI
Recent advances in the synthesis of pyrroles by multicomponent reactions
TLDR
This work describes the progress made in this area in the period between mid-2009 and the end of 2013 by describing the ready availability of suitably substituted and functionalized pyrrole derivatives.Abstract:
Pyrrole is one of the most important one-ring heterocycles. The ready availability of suitably substituted and functionalized pyrrole derivatives is essential for the progress of many branches of science, including biology and materials science. Access to this key heterocycle by multicomponent routes is particularly attractive in terms of synthetic efficiency, and also from the environmental point of view. We update here our previous review on this topic by describing the progress made in this area in the period between mid-2009 and the end of 2013.read more
Citations
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Exploration of Visible-Light Photocatalysis in Heterocycle Synthesis and Functionalization: Reaction Design and Beyond.
TL;DR: This Account presents a panoramic view and the logic of the recent contributions to the design, development, and application of photocatalytic systems and reactions that provide not only methods for the efficient synthesis of heterocycles but also useful insights into the exploration of new photochemical reactions.
Journal ArticleDOI
Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions
TL;DR: Deep eutectic solvents (DESs) have become more and more attractive in recent years due to their interesting properties and benefits, such as low cost of components, easy to prepare, tunable physicochemical properties, negligible vapor pressure, non-toxicity, biorenewability and biodegradability as mentioned in this paper.
Journal ArticleDOI
Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
TL;DR: In this review, attempts have been made to disclose various tactical approaches to synthesize pyrrole and pyr role containing analogs along with their therapeutic applications which have been reported during last decade.
Journal ArticleDOI
Metal-Free Multicomponent Syntheses of Pyridines
Journal ArticleDOI
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
References
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Recent developments in isocyanide based multicomponent reactions in applied chemistry
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Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
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B. Barry Touré,Dennis G. Hall +1 more
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"Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.
TL;DR: This review details developments of new, highly atom-economic MCR derived chemical methods, which enable the fast and efficient production of chemical libraries comprised of a variety of biologically relevant templates, and focuses on applications of isocyanide based MCR (IMCR) reactions.
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Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles
TL;DR: The present review is a transition metal-catalyzed synthesis of aromatic monocyclic heterocycles, aiming at achieving greater levels of molecular complexity and better functional group compatibilities in a convergent and atom economical fashions from readily accessible starting materials and under mild reaction conditions.