Recorded and Reported Sleepiness: The Association Between Brain Arousal in Resting State and Subjective Daytime Sleepiness.
Philippe Jawinski,Jennifer Kittel,Christian Sander,Jue Huang,Janek Spada,Christine Ulke,Kerstin Wirkner,Tilman Hensch,Ulrich Hegerl +8 more
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TLDR
The association between VIGALL variables of EEG vigilance (indicating brain arousal in resting state) and subjective daytime sleepiness in the LIFE cohort study approximates prior ESS-Multiple Sleep Latency Test results.Abstract:
Objectives Daytime sleepiness is a significant public health concern. Early evidence points toward the computerized VIGALL (Vigilance Algorithm Leipzig) as time-efficient tool to assess sleepiness objectively. In the present study, we investigated the association between VIGALL variables of EEG vigilance (indicating brain arousal in resting state) and subjective daytime sleepiness in the LIFE cohort study. Additionally, we validated VIGALL against the self-rated likelihood of having fallen asleep during the conducted resting EEG and against heart periods. Methods Participants of the primary sample LIFE 60+ (N = 1927, 60-79 years) and replication sample LIFE 40+ (N = 293, 40-56 years) completed the Epworth Sleepiness Scale (ESS). After an average interval of 3 weeks (LIFE 60+) and 65 weeks (LIFE 40+), respectively, participants underwent a single 20-minute resting EEG, analyzed using VIGALL 2.1. Results Analyses revealed significant associations between ESS and EEG vigilance in LIFE 60+ (rho = -0.17, p = 1E-14) and LIFE 40+ (rho = -0.24, p = 2E-5). Correlations between EEG vigilance and self-rated sleep likelihood reached rho = -0.43 (p = 2E-91) in LIFE 60+ and rho = -0.50 (p = 5E-20) in LIFE 40+. Overall, strongest correlations were obtained for EEG vigilance variable "slope index." Furthermore, lower EEG vigilance was consistently associated with longer heart periods. Conclusions The present study contributes to the validation of VIGALL. Despite the considerable interval between ESS and EEG assessment dates, the strength of ESS-VIGALL association approximates prior ESS-Multiple Sleep Latency Test results. In this light, VIGALL might constitute an economical choice for the objective assessment of daytime sleepiness in large cohort studies. The discriminative power to identify disorders of hypersomnolence, however, remains to be addressed.read more
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Brain arousal regulation in adults with attention-deficit/hyperactivity disorder (ADHD)
Maria Strauß,Christine Ulke,Madlen Paucke,Jue Huang,Nicole Mauche,Christian Sander,Tetyana Stark,Ulrich Hegerl +7 more
TL;DR: These findings support the arousal regulation model of ADHD, which interprets hyperactivity and sensation seeking as an autoregulatory reaction to an unstable regulation of brain arousal, and EEG-based arousal parameters may be candidate biomarkers for adult ADHD.
Journal ArticleDOI
Human brain arousal in the resting state: a genome-wide association study
Philippe Jawinski,Holger Kirsten,Holger Kirsten,Christian Sander,Janek Spada,Christine Ulke,Jue Huang,Ralph Burkhardt,Markus Scholz,Tilman Hensch,Ulrich Hegerl +10 more
TL;DR: The present GWAS identifies TMEM159 as a novel candidate gene which may modulate the risk for psychiatric disorders through arousal mechanisms and encourages the elaboration of the previously reported interrelations between ion-channel modulators, sleep-wake behavior, and psychiatric disorders.
Journal ArticleDOI
Vulnerability to bipolar disorder is linked to sleep and sleepiness.
Tilman Hensch,David Wozniak,Janek Spada,Christian Sander,Christine Ulke,Dirk Alexander Wittekind,Joachim Thiery,Markus Löffler,Philippe Jawinski,Philippe Jawinski,Ulrich Hegerl,Ulrich Hegerl +11 more
TL;DR: Strong evidence is found that higher HPS scores are associated with greater intraindividual sleep variability, more disturbed sleep and more daytime sleepiness, and factor analyses revealed that core hypomanic features were especially associated with self-reported sleep impairments.
Journal ArticleDOI
Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression
Christine Ulke,Craig E. Tenke,Jürgen Kayser,Christian Sander,Daniel Böttger,Lidia Y.X. Wong,Jorge E. Alvarenga,Maurizio Fava,Patrick J. McGrath,Patricia J. Deldin,Melvin G. McInnis,Madhukar H. Trivedi,Myrna M. Weissman,Diego A. Pizzagalli,Ulrich Hegerl,Gerard E. Bruder +15 more
TL;DR: Comparing measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project set the stage for examining the value of these measures for predicting clinical response to antidepressants in the entire EMBARC sample and evaluating whether an upregulated brain arousal is particularly characteristic for responders to antidepressants.
References
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A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
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