Journal ArticleDOI
Recruitment of elderly volunteers for a multicenter clinical trial: the SHEP pilot study.
TLDR
The SHEP experience indicates that older persons are willing to volunteer for clinical trials research and that problems of inference are probably not any greater for that age group than for any other.About:
This article is published in Controlled Clinical Trials.The article was published on 1986-06-01. It has received 93 citations till now. The article focuses on the topics: Population & Cohort.read more
Citations
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Journal ArticleDOI
Representation of Elderly Persons and Women in Published Randomized Trials of Acute Coronary Syndromes
TL;DR: Women and elderly persons remain underrepresented in published trial literature relative to their disease prevalence because safety and efficacy can vary as a function of sex and age, and these enrollment biases undermine efforts to provide evidence-based care to all cardiac patients.
Journal ArticleDOI
Aging Biology and Geriatric Clinical Pharmacology
TL;DR: A deficient therapeutic evidence base suggests that extrapolation of risk-benefit ratios from younger adults to geriatric populations is not necessarily valid, and therapeutic advances generally may convert healthy longevity from an asset of fortunate individuals into a general social benefit.
Journal ArticleDOI
Recruitment of adults 65 years and older as participants in the cardiovascular health study
Grethe S. Tell,Linda P. Fried,Bonnie Hermanson,Teri A. Manolio,Anne B. Newman,Nemat O. Borhani +5 more
TL;DR: Data from a subsample indicate that compared to those who were ineligible or who refused, enrolled participants were younger, more highly educated, more likely to be married, and less likely to report limitations in activity.
Journal ArticleDOI
Recruitment for controlled clinical trials: Literature summary and annotated bibliography
Laura C. Lovato,Kristin Hill,Stephanie Hertert,Donald B. Hunninghake,Jeffrey L. Probstfield,Jeffrey L. Probstfield +5 more
TL;DR: This article is a literature summary and annotated bibliography of research on recruitment for controlled clinical trials published through 1995, and annotate here 91 outstanding articles useful for formulation of overall recruitment approaches in clinical trials.
Journal ArticleDOI
First‐line drugs for hypertension
TL;DR: First-line low-dose thiazides reduce all morbidity and mortality outcomes and first-line ACE inhibitors and calcium channel blockers are inferior to first-liners beta-blockers.
References
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Journal Article
Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129mmHg
Journal ArticleDOI
Perspectives on systolic hypertension. The Framingham study.
TL;DR: Isolated systolic hypertension was related to the occurrence of “direct” complications as well as to atherosclerotic sequelae and was also associated with excess mortality, taking into account rigid vessels as judged from pulse-wave recordings.
Journal ArticleDOI
The Mind and mood of aging : mental health problems of the community elderly in New York and London
TL;DR: In-depth reports of an international study devoted to the comparative needs and care of community elderly in two English-speaking countries.
Journal ArticleDOI
The systolic hypertension in the elderly program
TL;DR: The conditions known as predominantly systolic hypertension" and "isolated systolics hypertension" have been recognized and ISH is thought to be mainly the end result of progressive arteriosclerotic changes in the media of the aorta and its large branches, with a loss of elastic fibers and an increase in the amount of cross
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