Regulation of mitochondrial pyruvate carboxylation and gluconeogenesis in rat hepatocytes via an alpha-adrenergic, adenosine 3':5'-monophosphate-independent mechanism.
J C Garrison,M K Borland +1 more
TLDR
The observation that catecholamines do not increase gluconeogenesis to the same extent as glucagon was not due to a differential effect on mitochondrial CO2 fixation, but to a smaller inhibition of pyruvate kinase activity than did glucagon.About:
This article is published in Journal of Biological Chemistry.The article was published on 1979-02-25 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Pyruvate kinase & Pyruvate dehydrogenase kinase.read more
Citations
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The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism.
TL;DR: The methods by which the intra-mitochondrial volume is measured both in vitro and in situ are described, the mechanisms thought to regulate the mitochondrial volume are summarised and evidence that changes in mitochondrial volume may be important in the responses of a variety of tissues to hormones and other stimuli is provided.
Journal ArticleDOI
Hormonal effects on calcium homeostasis in isolated hepatocytes.
TL;DR: The data indicate that the mitochondrial calcium pool is highly labile and is influenced by an as yet unknown transducing signal which is regulated by interaction of a-adrenergic hormones with the plasma membrane receptor.
Journal ArticleDOI
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide
Juan C. Sáez,David C. Spray,Angus C. Nairn,Elliot L. Hertzberg,Paul Greengard,Michael V. L. Bennett +5 more
TL;DR: The rapid increases in gap junctional conductance caused by agents that elevate cAMP and phosphorylation of the gap junction protein by cAMP-dependent protein kinase suggest that camp-dependent phosphorylated of thegap junction channel modulates the conductance of liver gap junctions.
Journal ArticleDOI
Role of calcium in the hormonal regulation of liver metabolism
Journal ArticleDOI
Structure, function and regulation of pyruvate carboxylase
Sarawut Jitrapakdee,J C Wallace +1 more
TL;DR: Different physiological conditions, including diabetes, hyperthyroidism, genetic obesity and postnatal development, increase the level of PC expression through transcriptional and translational mechanisms, whereas insulin inhibits PC expression.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate
TL;DR: A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase.
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Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.
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Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.
TL;DR: The effects of epinephrine and phenylephrine on carbohydrate metabolism in rat liver parenchymal cells are mediated predominantly by alpha-adrenergic receptors, and Stimulation of these receptors by epinphrine or phenylphrine results in activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase by mechanisms not involving an increase in cellular cAMP.
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On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase
TL;DR: The data are interpreted in favour of a role of calcium as the second messenger in liver for the three cyclic AMP-independent glycogenolytic hormones and as an additional messenger for glucagon which, via cyclicAMP, will make calcium available to the cytoplasm either from extracellular or from intracellular pools.