Regulation of Ribosome Biogenesis
Keiko Mizuta
- Vol. 51, Iss: 9, pp 609-614
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The article was published on 2013-01-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Ribosome biogenesis.read more
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Nuclear PI3K signaling in cell growth and tumorigenesis
TL;DR: Recent advances made toward elucidating the nuclear PI3K/Akt signaling cascade and its key components within the nucleus as they pertain to cell growth and tumorigenesis are summarized.
Journal ArticleDOI
Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae
TL;DR: A novel automated pipeline is developed and used to measure the expression of a TORC1-dependent ribosome biogenesis gene (NSR1) during osmotic stress in 4700 Saccharomyces cerevisiae strains from the yeast knock-out collection, leading to the identification of 440 strains with significant and reproducible defects in NSR1 repression.
Journal ArticleDOI
Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies
TL;DR: Nucleolar stress (loss of ribosome production/function) in certain human progenitor or stem cells results in disease in fruit flies, and larval mushroom body neuroblasts are relatively resilient to nucleolar stress.
Journal ArticleDOI
Reduction of Ribosome Level Triggers Flocculation of Fission Yeast Cells
Rongpeng Li,Xuesong Li,Lei Sun,Feifei Chen,Zhenxing Liu,Yuyu Gu,Xiaoyan Gong,Zhonghua Liu,Hua Wei,Ying Huang,Sheng Yuan +10 more
TL;DR: In this article, the reduction of ribosomal levels in sexual flocculating cells was caused by more-extensive suppression of gene expression, while the reduction was due to an imbalance between ribosome proteins.
Journal ArticleDOI
Response of Resistance Exercise-Induced Muscle Protein Synthesis and Skeletal Muscle Hypertrophy Are Not Enhanced After Disuse Muscle Atrophy in Rat.
TL;DR: Results showed that MPS and mTORC1 activity was unchanged after HS at basal state, and MPS in response to acute RE and muscle hypertrophy in Response to chronic RT were unaltered after disuse muscle atrophy.
References
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Journal ArticleDOI
Loss of ribosomal RNA modification causes developmental defects in zebrafish
Sayomi Higa-Nakamine,Takeo Suzuki,Tamayo Uechi,Anirban Chakraborty,Yukari Nakajima,Mikako Nakamura,Naoko Hirano,Tsutomu Suzuki,Naoya Kenmochi +8 more
TL;DR: It is found that decreased snoRNA expression reduces the snoRNAs-guided methylation of the target nucleotides, which suggests that rRNA modifications play an essential role in vertebrate development.
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Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing
Michael Gamalinda,Jelena Jakovljevic,Reyes Babiano,Jason Talkish,Jesús de la Cruz,John L. Woolford +5 more
TL;DR: Data support that L17, L35 and L37 are specifically required for a recruiting step immediately preceding removal of ITS2, which is required for 60S subunit formation as a consequence of their role in removal of the ITS2 spacer from 27SB pre-rRNA.
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Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres
TL;DR: The results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomeres tethering, by binding Sir4.
Journal ArticleDOI
Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3′-extension of 5S rRNA in Saccharomyces cerevisiae
TL;DR: In vivo and in vitro binding assays indicate that Rrs1p interacts with the ribosomal protein L5–5S rRNA complex, and conditionally synthetic lethal allele with the rrs1-5 mutation weakens the interaction between RRS1p with both L5 and L11.