Protein factors involved in the biogenesis of the mitochondrial ribosome
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The article was published on 2018-02-06 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Ribosome assembly & Mitochondrial ribosome.read more
Citations
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Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing
Bryan William Davies,Caroline Köhrer,Asha I. Jacob,Lyle A. Simmons,Lyle A. Simmons,Jianyu Zhu,Lourdes M. Aleman,Uttam L. RajBhandary,Graham C. Walker +8 more
TL;DR: In this article, the UPF0054 protein family is shown to have a significant effect on the maturation of the Escherichia coli homologue, YbeY.
with mutations in the tRNA nucleotidyl transferase TRNT1
Florin Sasarman,Isabelle Thiffault,Woranontee Weraarpachai,Steven Salomon,Catalina Maftei,Julie Gauthier,Benjamin Ellazam,Neil Webb,Hana Antonicka,Alexandre Janer,Catherine Brunel-Guitton,Orly Elpeleg,Grant A. Mitchell,Jacques Roboh,Eric A. Shoubridge +14 more
TL;DR: In this paper, the trinucleotide cytosine/cytosine-/adenine (CCA) is added to the 3' end of transfer RNAs (tRNAs) for translation and is catalyzed by the enzyme TRNT1 (tRNA nucleotidyl transferase), which functions in both the cytoplasm and mitochondria.
References
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Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
The Sequence Alignment/Map format and SAMtools
Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
TL;DR: SAMtools as discussed by the authors implements various utilities for post-processing alignments in the SAM format, such as indexing, variant caller and alignment viewer, and thus provides universal tools for processing read alignments.
Journal ArticleDOI
Sequence and organization of the human mitochondrial genome
Stephen Anderson,Alan T. Bankier,Bart Barrell,M.H.L. de Bruijn,Alan Coulson,J. Drouin,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Donald P. Nierlich,Bruce A. Roe,Bruce A. Roe,Frederick Sanger,P. H. Schreier,Andrew J.H. Smith,Rodger Staden,Ian G. Young,Ian G. Young +17 more
TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Journal ArticleDOI
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
TL;DR: This article proposes an elegantly simple multi-seed strategy, called seed-and-vote, for mapping reads to a reference genome, which uses a relatively large number of short seeds extracted from each read and allows all the seeds to vote on the optimal location.
Journal ArticleDOI
tRNA punctuation model of RNA processing in human mitochondria
TL;DR: It is proposed that the H strand is transcribed into a single polycistronic RNA molecule, which is processed later into mature species by precise endonucleolytic cleavages which occur, in most cases, immediately before and after a tRNA sequence.