Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation
TLDR
Cmg, the Drosophila homolog of CASK/Lin-2, associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMK II, which provides a mechanism by which the active postsynaptic pool of Ca MKII can be controlled locally to differentiate active and inactive synapses.About:
This article is published in Neuron.The article was published on 2003-12-18 and is currently open access. It has received 108 citations till now. The article focuses on the topics: Ca2+/calmodulin-dependent protein kinase & Autophosphorylation.read more
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Nova regulates brain-specific splicing to shape the synapse
Jernej Ule,Aljaž Ule,Joanna L. Spencer,Alan Williams,Jing Shan Hu,Melissa S. Cline,Hui Wang,Tyson A. Clark,Claire E. Fraser,Matteo Ruggiu,Barry R. Zeeberg,David W. Kane,John N. Weinstein,John E. Blume,Robert B. Darnell +14 more
TL;DR: Validating a large set of Nova RNA targets has led us to identify a multi-tiered network in which Nova regulates the exon content of RNAs encoding proteins that interact in the synapse, which may contribute to tissue-specific functions.
Journal ArticleDOI
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions
TL;DR: Diverse roles in tissue development, differentiation, and physiology are explained by recent biochemical and structural analyses of MAGUKs, which demonstrate their capacity to assemble well--efined--yet adaptable--protein complexes at cellular junctions.
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Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme
TL;DR: The structure of the kinase dimer, when combined with small-angle X-ray scattering data for the holoenzyme, suggests that inactive CaMKII forms tightly packed autoinhibited assemblies that convert upon activation into clusters of loosely tethered and independent kinase domains.
Journal ArticleDOI
Calcium/calmodulin-dependent protein kinase II and synaptic plasticity.
TL;DR: Recent progress brings us closer to understanding the regulation of dendritic CaMKII activity, localization, and expression, and its role in modulating synaptic transmission and cell morphology.
Journal ArticleDOI
CaMKII regulation in information processing and storage
TL;DR: Emerging evidence supports a direct role in information processing, while storage of synaptic information may instead be mediated by regulated interaction of CaMKII with the NMDA receptor (NMDAR) complex.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Andrea H. Brand,Norbert Perrimon +1 more
TL;DR: The GAL4 system, a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns, has been designed and used to expand the domain of embryonic expression of the homeobox protein even-skipped.
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Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
TL;DR: Both postsynaptic PKC and CaMKII are required for the induction of LTP and a presynaptic protein kinase appears to be necessary for the expression of L TP, and both post synapses and protein kinases are sensitive to externally applied H-7.
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Interaction with the NMDA receptor locks CaMKII in an active conformation
K. Ulrich Bayer,Paul De Koninck,Paul De Koninck,A. Soren Leonard,A. Soren Leonard,Johannes W. Hell,Johannes W. Hell,Howard Schulman +7 more
TL;DR: It is shown that regulated CaMKII interaction with two sites on the NMDA receptor subunit NR2B provides a mechanism for the glutamate-induced translocation of the kinase to the synapse in hippocampal neurons.
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Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation
Kang Shen,Tobias Meyer +1 more
TL;DR: It is shown that N-methyl-D-aspartate (NMDA) receptor stimulation reversibly translocates green fluorescent protein-tagged CaMKII from an F-actin-bound to a PSD-bound state.